Ground-based selected ionizing space radiation effects on stability of APIs and their formulations

Autor: Dhara Bhayani, Priti Mehta, Manali Patel, Haladhara Naik, T. Newton Nathaniel, Saif Khan
Rok vydání: 2022
Předmět:
Zdroj: Journal of pharmaceutical and biomedical analysis. 220
ISSN: 1873-264X
Popis: Primary goal of any space mission is to keep astronauts healthy and fit during entire mission. One of the important challenges for that is providing a safe and effective pharmacy with the capabilities to address both scheduled and unanticipated medical conditions that may arise during spaceflight. Extended exposure to space environmental conditions may trigger drug deterioration, impacting quality, effectiveness, and safety. To assess the influence of space ionizing radiations on the stability of medicines launched aboard spacecraft, a preliminary ground-based ionizing radiation drug interaction study was carried out at different doses in the present work. Four different types of radiations - proton, neutron (thermal, fast), gamma and heavy ions (
Databáze: OpenAIRE