Geraniol modulates tongue and hepatic phase I and phase II conjugation activities and may contribute directly to the chemopreventive activity against experimental oral carcinogenesis
| Autor: | Thiruvengadam Devaki, Subramaniyan Jayakumar, Selvamani Asokkumar, Subramanian Raghunandhakumar, Arumugam Madankumar, Krishnan Gokuladhas, Balan Rajan |
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| Rok vydání: | 2013 |
| Předmět: |
Male
NF-E2-Related Factor 2 Acyclic Monoterpenes medicine.medical_treatment 4-Nitroquinoline 1-oxide Pharmacology medicine.disease_cause chemistry.chemical_compound Cytochrome P-450 Enzyme System Oral administration Microsomes Detoxification medicine Animals Anticarcinogenic Agents Rats Wistar Carcinogen Chemotherapy Terpenes Cancer medicine.disease 4-Nitroquinoline-1-oxide Rats Tongue Neoplasms Cytochromes b5 Liver Biochemistry chemistry Carcinogens Carcinogenesis Geraniol |
| Zdroj: | European Journal of Pharmacology. 705:148-155 |
| ISSN: | 0014-2999 |
| Popis: | Xenobiotic metabolizing enzymes are chief determinants in both the susceptibility to mutagenic effect of chemical carcinogens and in the response of tumors to chemotherapy. The present study was aimed to analyze the effect of geraniol administration on the activity of phase I and phase II carcinogen metabolizing enzymes through the nuclear factor erythroid 2-related factor-2 (Nrf2) activation against 4-niroquinoline-1-oxide (4NQO) induced oral carcinogenesis. The well-known chemical carcinogen 4NQO (50 ppm) was used to induce oral carcinogenesis through drinking water for 4, 12, and 20 weeks. The degree of cancer progression at each stage was confirmed by histological examination. At the end of the experimental period, 100% tumor formation was observed in the oral cavity of 4NQO induced animals with significant (P |
| Databáze: | OpenAIRE |
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