Decreased Glucocorticoid Signaling Potentiates Lipid-Induced Inflammation and Contributes to Insulin Resistance in the Skeletal Muscle of Fructose-Fed Male Rats Exposed to Stress
| Autor: | Ana Teofilović, Ana Djordjevic, Abdulbaset Zidane Shirif, Sanja Kovačević, Jelena Brkljačić, Gordana Matić, Ivana Elaković |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_treatment fructose 0302 clinical medicine Glucocorticoid receptor lipid metabolism Biology (General) Spectroscopy 2. Zero hunger biology glucocorticoids Chemistry General Medicine Computer Science Applications medicine.anatomical_structure Glucocorticoid Signal Transduction medicine.drug medicine.medical_specialty insulin QH301-705.5 030209 endocrinology & metabolism Models Biological Catalysis Article Inorganic Chemistry 03 medical and health sciences Receptors Glucocorticoid Insulin resistance Stress Physiological Internal medicine medicine Animals Humans Rats Wistar Physical and Theoretical Chemistry skeletal muscle Muscle Skeletal Molecular Biology Protein kinase B QD1-999 chronic stress Inflammation Insulin Organic Chemistry Skeletal muscle Lipid metabolism medicine.disease Rats Insulin receptor 030104 developmental biology Endocrinology biology.protein Insulin Resistance |
| Zdroj: | International Journal of Molecular Sciences Volume 22 Issue 13 International Journal of Molecular Sciences, Vol 22, Iss 7206, p 7206 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22137206 |
| Popis: | The modern lifestyle brings both excessive fructose consumption and daily exposure to stress which could lead to metabolic disturbances and type 2 diabetes. Muscles are important points of glucose and lipid metabolism, with a crucial role in the maintenance of systemic energy homeostasis. We investigated whether 9-week fructose-enriched diet, with and without exposure to 4-week unpredictable stress, disturbs insulin signaling in the skeletal muscle of male rats and evaluated potential contributory roles of muscle lipid metabolism, glucocorticoid signaling and inflammation. The combination of fructose-enriched diet and stress increased peroxisome proliferator-activated receptors-α and -δ and stimulated lipid uptake, lipolysis and β-oxidation in the muscle of fructose-fed stressed rats. Combination of treatment also decreased systemic insulin sensitivity judged by lower R-QUICKI, and lowered muscle protein content and stimulatory phosphorylations of insulin receptor supstrate-1 and Akt, as well as the level of 11β-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor. At the same time, increased levels of protein tyrosine phosphatase-1B, nuclear factor-κB, tumor necrosis factor-α, were observed in the muscle of fructose-fed stressed rats. Based on these results, we propose that decreased glucocorticoid signaling in the skeletal muscle can make a setting for lipid-induced inflammation and the development of insulin resistance in fructose-fed stressed rats. |
| Databáze: | OpenAIRE |
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