Estrous cycle and ovariectomy-induced changes in visceral pain are microbiota-dependent
| Autor: | John F. Cryan, James M. Collins, Siobhain M. O' Mahony, Mónica Tramullas, Patrick Fitzgerald, Timothy G. Dinan |
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| Přispěvatelé: | Universidad de Cantabria |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Estrous cycle
Abdominal pain medicine.medical_specialty Multidisciplinary biology business.industry Science Visceral pain Gut flora biology.organism_classification medicine.disease Article Endocrinology Internal medicine Sensation medicine Microbiome medicine.symptom business Weight gain Irritable bowel syndrome Neuroscience |
| Zdroj: | iScience . 2021 Jul 10;24(8):102850 iScience iScience, Vol 24, Iss 8, Pp 102850-(2021) UCrea Repositorio Abierto de la Universidad de Cantabria Universidad de Cantabria (UC) |
| Popis: | Summary Visceral hypersensitivity (VH) is a hallmark of many functional gastrointestinal disorders including irritable bowel syndrome and is categorized by a dull, diffuse sensation of abdominal pain. Recently, the gut microbiota has been implicated in VH in male mice, but the effects in females have yet to be explored fully. To this end, we now show that somewhat surprisingly, female germ-free mice have similar visceral pain responses to colorectal distension (CRD) as their conventional controls. However, we show that although sensitivity to CRD is estrous cycle stage-dependent in conventional mice, it is not in germ-free mice. Further, ovariectomy (OVX) induced VH in conventional but not germ-free mice, and induced weight gain regardless of microbiota status. Finally, we show that estrogen-replacement ameliorated OVX-induced VH. Taken together, this study provides evidence for a major role of female sex hormones and the gut microbiota in sensation of visceral pain in females. Graphical abstract Highlights • The visceral pain response is estrous cycle-dependent in conventional females only • Ovariectomy induced visceral hypersensitivity in control but not germ-free females • Ovariectomy-induced visceral hyperalgesia is ameliorated by estrogen replacement • Novel findings on estrous cycle-dependent mechanisms of visceral pain Endocrinology ; Microbiome; Neuroscience |
| Databáze: | OpenAIRE |
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