Towards a biological staging model for operable non-small cell lung cancer

Autor: Al Harris, Gerard Cox, K C Gatter, A Andi, Kenneth J. O'Byrne, Daniel E.B. Swinson, J Lolljee, Alexandra Giatromanolaki, J. L. Jones, M I Koukourakis, David A. Waller, D Richardson, John G. Edwards
Rok vydání: 2001
Předmět:
Adult
Male
Pulmonary and Respiratory Medicine
Oncology
Cancer Research
medicine.medical_specialty
Pathology
Prognostic variable
Lung Neoplasms
Small-cell carcinoma
chemistry.chemical_compound
Growth factor receptor
Epidermal growth factor
Carcinoma
Non-Small-Cell Lung
Internal medicine
Biomarkers
Tumor
medicine
Humans
Epidermal growth factor receptor
Lung cancer
Prospective cohort study
Aged
Neoplasm Staging
Retrospective Studies
Neovascularization
Pathologic
biology
business.industry
Microcirculation
Genes
erbB-2
Middle Aged
Prognosis
medicine.disease
ErbB Receptors
Gene Expression Regulation
Neoplastic
Vascular endothelial growth factor
Matrix Metalloproteinase 9
Proto-Oncogene Proteins c-bcl-2
chemistry
biology.protein
Matrix Metalloproteinase 2
Female
Tumor Suppressor Protein p53
business
Zdroj: Scopus-Elsevier
ISSN: 0169-5002
DOI: 10.1016/s0169-5002(01)00352-x
Popis: Non-small cell lung cancer is the most common cause of cancer-related death in North America and Europe. Despite improvements in the diagnosis and treatment of the disease the prognosis remains poor, the overall 5-year survival being 4–14%. An increased understanding of the molecular biology of the disease may identify novel targets for drug development. We evaluated epidermal growth factor receptor (EGFR), HER-2/neu, matrix metalloproteinase (MMP)-2, MMP-9, p53 and bcl-2 expression and microvessel density (MVD) in patients who underwent surgery with curative intent in our department between 1991 and 1996. Co-expression of EGFR/MMP-9, MVD and bcl-2 were found to be independent prognostic variables, which allowed prediction of patient outcome independent of surgical stage. Other prognostic factors identified in our series were gender, surgical stage, platelet count, extent of necrosis, the hypoxia marker carbonic anhydrase-9 and β-catenin. In collaboration with groups in Oxford and Greece, we were also able to establish the angiogenic growth factors vascular endothelial growth factor and platelet-derived endothelial growth factor as prognostic variables. The inter-relationships between these factors are currently being examined in an expanded patient series. Through this work we hope to be able to construct an integrated biological prognostic model which can be tested in prospective studies. This work has identified several potential targets for novel therapeutic agents currently in development.
Databáze: OpenAIRE
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