Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa
| Autor: | Ahuno, Samuel Terkper, Doebley, Anna-Lisa, Ahearn, Thomas U, Yarney, Joel, Titiloye, Nicholas, Hamel, Nancy, Adjei, Ernest, Clegg-Lamptey, Joe-Nat, Edusei, Lawrence, Awuah, Baffour, Song, Xiaoyu, Vanderpuye, Verna, Abubakar, Mustapha, Duggan, Maire, Stover, Daniel G, Nyarko, Kofi, Bartlett, John MS, Aitpillah, Francis, Ansong, Daniel, Gardner, Kevin L, Boateng, Felix Andy, Bowcock, Anne M, Caldas, Carlos, Foulkes, William D, Wiafe, Seth, Wiafe-Addai, Beatrice, Garcia-Closas, Montserrat, Kwarteng, Alexander, Ha, Gavin, Figueroa, Jonine D, Polak, Paz, Ghana Breast Health Study Team |
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| Přispěvatelé: | Doebley, Anna-Lisa [0000-0002-3371-3352], Abubakar, Mustapha [0000-0003-3728-6535], Duggan, Maire [0000-0001-6625-7683], Bartlett, John MS [0000-0002-0347-3888], Aitpillah, Francis [0000-0001-9495-6887], Caldas, Carlos [0000-0003-3547-1489], Foulkes, William D [0000-0001-7427-4651], Wiafe, Seth [0000-0001-6085-9405], Ha, Gavin [0000-0001-7578-7272], Figueroa, Jonine D [0000-0002-5100-623X], Polak, Paz [0000-0002-2153-4488], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Brief Communication DNA sequencing Tumor grade chemistry.chemical_compound Breast cancer Cancer genomics medicine RC254-282 Cancer Molecular medicine Molecular pathology business.industry Non invasive Neoplasms. Tumors. Oncology. Including cancer and carcinogens Diagnostic markers medicine.disease Ghana Breast Health Study Team Oncology chemistry Circulating tumor DNA Cancer research business DNA |
| Zdroj: | npj Precision Oncology, Vol 5, Iss 1, Pp 1-8 (2021) 2021, ' Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa ', npj Precision Oncology . https://doi.org/10.1038/s41698-021-00219-7 NPJ Precision Oncology |
| ISSN: | 2397-768X |
| DOI: | 10.1038/s41698-021-00219-7 |
| Popis: | Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients. |
| Databáze: | OpenAIRE |
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