Orbital medulloepithelioma in an adult patient: Radiation-induced second neoplasia?

Autor:	Antony George Francis Thottian, Rony Benson, Seema Kashyap, Subhash Gupta, K.P. Haresh, Goura Kishor Rath, Dayanand Sharma
Rok vydání:	2016
Předmět:	Adult Male medicine.medical_specialty Pathology Neoplasms Radiation-Induced Retinal Neoplasm Retinal Neoplasms Population 03 medical and health sciences 0302 clinical medicine Germline mutation Antineoplastic Combined Chemotherapy Protocols Proton Therapy medicine Humans Neuroectodermal Tumors Primitive education education.field_of_study Retinoblastoma business.industry Radiotherapy Planning Computer-Assisted Incidence (epidemiology) medicine.disease Magnetic Resonance Imaging Dermatology eye diseases Ophthalmology 030220 oncology & carcinogenesis Hereditary Retinoblastoma 030221 ophthalmology & optometry Second Malignancy Orbital Neoplasms Medulloepithelioma Tomography X-Ray Computed business
Zdroj:	Orbit. 35:313-316
ISSN:	1744-5108 0167-6830
Popis:	Second cancers in survivors of hereditary retinoblastoma occur much more commonly than in the general population. This can be attributed both to the germline mutation of the RB gene and chemoradiation used for treatment of this paediatric cancer. Medulloepithelioma is an uncommon tumor of neuroectodermal origin, seen largely in the paediatric population and rarely reported in adults. Though the incidence of second malignancies is common in retinoblastoma, medulloepithelioma as a second malignancy in retinoblastoma survivors is rare, with only one case reported so far. Herein, we present a case of a 29-year-old patient presenting with medulloepithelioma of the right orbit, arising in the radiation field of previously treated retinoblastoma. This case was also peculiar in that though the origin of tumor was in the eyeball it had a very aggressive clinical course.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a0d51716af842218f5cb91d60858eb https://doi.org/10.1080/01676830.2016.1193536 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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