A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation
| Autor: | Susanne M. Kooistra, Lise Lotte Christensen, Kirsten Grønbæk, Anders H. Lund, Jakob Skou Pedersen, Kristian Helin, Sebastian M. Waszak, Yitzhak Pilpel, Hila Gingold, Torben F. Ørntoft, Morten Muhlig Nielsen, Disa Tehler, Claus L. Andersen, Elisabeth Ralfkiaer, Fazila Asmar, Karina Dalsgaard Sørensen, Lars Dyrskjot Andersen, Esther Hulleman, Michael Borre, Orna Dahan, Nanna R. Christoffersen, Nicolaj S. Christophersen, Thomas Wurdinger |
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| Přispěvatelé: | Pediatric surgery, Neurosurgery, CCA - Innovative therapy |
| Rok vydání: | 2014 |
| Předmět: |
Cellular differentiation
Histones/metabolism RNA Messenger/metabolism Messenger/metabolism Bioinformatics Cell Transformation General Biochemistry Genetics and Molecular Biology Cell Line Histones Transcriptome RNA Transfer Neoplasms Cell Line Tumor Translational regulation Protein biosynthesis Anticodon Humans RNA Messenger Codon Gene Cell Proliferation Neoplastic Tumor biology Biochemistry Genetics and Molecular Biology(all) Transfer/chemistry Cell Differentiation Neoplasms/genetics Cell biology Have You Seen? Histone Cell Transformation Neoplastic Codon usage bias Protein Biosynthesis Transfer RNA biology.protein RNA RNA Transfer/chemistry |
| Zdroj: | Cell, 158(6), 1281-1292. Cell Press Gingold, H, Tehler, D, Christoffersen, N R, Nielsen, M M, Asmar, F, Kooistra, S M, Christophersen, N S, Christensen, L L, Borre, M, Sorensen, K D, Andersen, L D, Andersen, C L, Hulleman, E, Wurdinger, T, Ralfkiaer, E, Helin, K, Gronbaek, K, Omtoft, T, Waszak, S M, Dahan, O, Pedersen, J S, Lund, A H & Pilpel, Y 2014, ' A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation ', Cell, vol. 158, no. 6, pp. 1281-1292 . https://doi.org/10.1016/j.cell.2014.08.011 Cell, 158(6), 1281-1292. CELL PRESS Scopus-Elsevier Gingold, H, Tehler, D, Christoffersen, N R, Nielsen, M M, Asmar, F, Kooistra, S M, Christophersen, N S, Christensen, L L, Borre, M, Sørensen, K D, Andersen, L D, Andersen, C L, Hulleman, E, Wurdinger, T, Ralfkiær, E, Helin, K, Grønbæk, K, Orntoft, T, Waszak, S M, Dahan, O, Pedersen, J S, Lund, A H & Pilpel, Y 2014, ' A dual program for translation regulation in cellular proliferation and differentiation ', Cell, vol. 158, no. 6, pp. 1281-92 . https://doi.org/10.1016/j.cell.2014.08.011 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2014.08.011 |
| Popis: | A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the opposite signature. Correspondingly, we found that genes serving cell-autonomous functions and genes involved in multicellularity obey distinct codon usage. Proliferation-induced and differentiation-induced tRNAs often carry anticodons that correspond to the codons enriched among the cell-autonomous and the multicellularity genes, respectively. Because mRNAs of cell-autonomous genes are induced in proliferation and cancer in particular, the concomitant induction of their codon-enriched tRNAs suggests coordination between transcription and translation. Histone modifications indeed change similarly in the vicinity of cell-autonomous genes and their corresponding tRNAs, and in multicellularity genes and their tRNAs, suggesting the existence of transcriptional programs coordinating tRNA supply and demand. Hence, we describe the existence of two distinct translation programs that operate during proliferation and differentiation. |
| Databáze: | OpenAIRE |
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