Optimization and assessment of a novel gastric electrode anchoring system designed to be implanted by minimally invasive surgery
| Autor: | Charlotte Sandersen, Hugo Smets, Laurent Lonys, Géraldine Bolen, Antoine Nonclercq, Stefan Deleuze, Pierre Lambert, Vicente Acuña, Jacques Devière, Anne Vanhoestenberghe, Fabrizio Giannotta, Sophie Egyptien, Adrien Debelle, Alain Delchambre, Erika Bianchini, Hilde De Rooster, François Huberland |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Gastric electrical stimulation
Materials science Percutaneous 0206 medical engineering Biomedical Engineering Biophysics Anchoring 02 engineering and technology Sciences de l'ingénieur Muscular layer 03 medical and health sciences Dogs 0302 clinical medicine Cadaver medicine In-vivo validation Animals Minimally Invasive Surgical Procedures Single incision surgery Device parameters Percutaneous implantation Electrode anchoring Stomach 020601 biomedical engineering Electrodes Implanted Ingénierie biomédicale medicine.anatomical_structure Electrode Invasive surgery 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Medical engineering & physics, 92 |
| Popis: | A novel electrode anchoring design and its implantation procedure, aiming for a minimally invasive solution for gastric electrical stimulation, are presented. The system comprises an anchor made of a flexible body embedding two needle-shaped electrodes. The electrodes can easily switch from a parallel position – to pierce the stomach – to a diverging position – enabling them to remain firmly anchored into the muscular layer of the stomach. Key device parameters governing anchoring stability were assessed on a traction test bench, and optimal values were derived. The device was then implanted in six dogs by open surgery to assess its anchoring durability in vivo. Computed tomography images showed that the electrodes remained well placed within the dogs’ gastric wall over the entire assessment period (more than one year). Finally, a prototype of a surgical tool for the minimally invasive device placement was manufactured, and the anchoring procedure was tested on a dog cadaver, providing the proof of concept of the minimally invasive implantation procedure. The use of our electrode anchoring system in long-term gastric electrical stimulation is promising in terms of implantation stability (the anchor withstands a force up to 0.81 N), durability (the anchor remains onto the stomach over one year) and minimal invasiveness of the procedure (the diameter of the percutaneous access is smaller than 12 mm). Moreover, the proposed design could have clinical applications in other hollow organs, such as the urinary bladder. info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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