Non-invasive isolation of rare circulating tumor cells with a DNA mimic of double-sided tape using multimeric aptamers

Autor:	Deependra Tyagi, Yongli Chen, Xu Zhang, Shengnan He, Shufen Cui, Andrew J. Carrier, Wei Wang
Rok vydání:	2019
Předmět:	Aptamer Cell Cell Separation 02 engineering and technology 010402 general chemistry Endocytosis 01 natural sciences chemistry.chemical_compound Circulating tumor cell Cell Line Tumor medicine Humans General Materials Science Magnetite Nanoparticles Whole blood Microscopy Confocal biology Chemistry DNA Aptamers Nucleotide Neoplastic Cells Circulating equipment and supplies 021001 nanoscience & nanotechnology 3. Good health 0104 chemical sciences medicine.anatomical_structure biology.protein Cancer research Antibody Reactive Oxygen Species 0210 nano-technology human activities Intracellular
Zdroj:	Nanoscale. 11:5879-5883
ISSN:	2040-3372 2040-3364
Popis:	Circulating tumor cells (CTCs) are indicative for cancer diagnosis and prognosis. However, conventional immuno-magnetic cell capture technologies using antibody- and aptamer-functionalized magnetic particles generate increased intracellular oxidative stress through endocytosis. Herein, we efficiently, selectively, and non-invasively isolate CTCs from whole blood by mimicking double-sided tape using DNA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a003e746d268a9784a04a5bba33d27 https://doi.org/10.1039/c9nr00364a Zobrazit plný text záznamu