Impairment of lymphocyte function in head-injured rats : Effects of standard and immune-enhancing diets for enteral nutrition

Autor: Joelle Nafziger, Jean-Claude Chaumeil, Michel Plotkine, Séverine Gupta, Linda Belabed, Christophe Moinard, Sophie Richon, Luc Cynober, Catherine Marchand-Verrecchia, Stéphane Walrand, Christine Charrueau, Valérie C. Besson
Přispěvatelé: Processus d’adaptation métaboliques et nouvelles stratégies nutritionnelles (EA 2498), Université Paris Descartes - Paris 5 (UPD5), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2003
Předmět:
Male
medicine.medical_specialty
medicine.medical_treatment
Lymphocyte
HEAD INJURY
[SDV]Life Sciences [q-bio]
Rat model
Thymus Gland
Arginine
Critical Care and Intensive Care Medicine
Enteral administration
Antioxidants
Rats
Sprague-Dawley
Random Allocation
03 medical and health sciences
Enteral Nutrition
0302 clinical medicine
Atrophy
Immune system
CD25 RECEPTOR
Sepsis
Internal medicine
Fatty Acids
Omega-3
medicine
Animals
Craniocerebral Trauma
Lymphocytes
DYSIMMUNITY
Saline
Food
Formulated
Nutrition and Dietetics
business.industry
030208 emergency & critical care medicine
medicine.disease
RECEPTEUR CD25
Rats
LYMPHOCYTE
ALIMENTATION IMMUNOMODULATRICE
Endocrinology
Parenteral nutrition
medicine.anatomical_structure
Immunology
Standard diet
IMMUNE-ENHANCING DIET
business
030217 neurology & neurosurgery
Zdroj: 23. Congrès de la SFNEP, Société Francophone de Nutrition Entérale et Parentérale
23. Congrès de la SFNEP, Société Francophone de Nutrition Entérale et Parentérale, Nov 2003, Gand, Belgium. ⟨10.1016/j.clnu.2006.02.003⟩
Clinical Nutrition
Clinical Nutrition, Elsevier, 2006, 25 (5), pp.832-841. ⟨10.1016/j.clnu.2006.02.003⟩
Clinical Nutrition, 2006, 25 (5), pp.832-841. ⟨10.1016/j.clnu.2006.02.003⟩
ISSN: 0261-5614
1532-1983
DOI: 10.1016/j.clnu.2006.02.003⟩
Popis: International audience; BACKGROUND: The metabolic response to head injury (HI) is characterized by a dysimmunity which may be a risk factor of a septic state. The use of immune enhancing diets (IEDs) could be a promising approach to improve immune functions. The aim of the study was to investigate the consequences of HI on lymphocyte function and to determine the effects of an enteral IED comparatively to a standard enteral nutrition. METHOD: A rat model of HI by fluid percussion was used. Twenty-five male Sprague-Dawley rats were randomized into 4 groups: rats receiving standard chow diet ad libitum (AL), rats sustaining HI and receiving standard chow diet and enteral saline (HI), rats receiving the enteral standard diet Sondalis HP (HIS), and rats receiving the IED Crucial (HIC). The two enteral diets were infused continuously during 4 days after the HI and were isocaloric, isonitrogenous and isovolumic. RESULTS: HI induced a thymus atrophy (HI vs. AL, P
Databáze: OpenAIRE
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