Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes
| Autor: | Ilpo Vattulainen, Piotr Jurkiewicz, Agnieszka Olżyńska, Heikki Mikkolainen, Waldemar Kulig, Tomasz Róg, Lukasz Cwiklik, Martin Hof, Pavel Jungwirth |
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| Přispěvatelé: | Department of Physics |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
BILAYERS Cell signaling Lipid Bilayers 116 Chemical sciences ENDOPLASMIC-RETICULUM Chromosomal translocation OXYGEN PERMEABILITY Molecular Dynamics Simulation METABOLISM CHOLESTEROL FLIP-FLOP 03 medical and health sciences General Materials Science Physical and Theoretical Chemistry Lipid bilayer 030102 biochemistry & molecular biology Chemistry LIPID-MEMBRANES Endoplasmic reticulum Cell Membrane SIDE-CHAIN OXYSTEROLS Biological membrane Oxysterols Metabolism Sterols Cholesterol 030104 developmental biology Membrane PLASMA-MEMBRANE SIMULATION Molecular mechanism Biophysics Thermodynamics 1182 Biochemistry cell and molecular biology lipids (amino acids peptides and proteins) ORIENTATION Oxidation-Reduction Signal Transduction |
| Zdroj: | The Journal of Physical Chemistry Letters. 9:1118-1123 |
| ISSN: | 1948-7185 |
| Popis: | Translocation of sterols between cellular membrane leaflets is of key importance in membrane organization, dynamics, and signaling. We present a novel translocation mechanism that differs in a unique manner from the established ones. The bobbing mechanism identified here is demonstrated for tail-oxidized sterols, but is expected to be viable for any molecule containing two polar centers at the opposite sides of the molecule. The mechanism renders translocation across a lipid membrane possible without a change in molecular orientation. For tail-oxidized sterols, the bobbing mechanism provides an exceptionally facile means to translocate these signaling molecules across membrane structures and may thus represent an important pathway in the course of their biological action. |
| Databáze: | OpenAIRE |
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