Endothelial function in subjects with isolated low HDL cholesterol: role of nitric oxide and circulating progenitor cells
| Autor: | Kazuaki Chayama, Hidekazu Umei, Junko Soga, Yasuki Kihara, Hidehiro Matsuoka, Yuichi Fujii, Ryo Sugano, Tsutomu Imaizumi, Yukihito Higashi |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Endothelium Physiology Vasodilator Agents Endocrinology Diabetes and Metabolism Biology Nitric Oxide Statistics Nonparametric Nitric oxide Cohort Studies Nitroglycerin Young Adult chemistry.chemical_compound High-density lipoprotein Reference Values Risk Factors Physiology (medical) Internal medicine medicine Humans Progenitor cell Aged Pravastatin Aged 80 and over Cholesterol Anticholesteremic Agents Stem Cells Cholesterol HDL nutritional and metabolic diseases Middle Aged Vasodilation Endocrinology medicine.anatomical_structure chemistry Cardiovascular Diseases Case-Control Studies Circulatory system Female lipids (amino acids peptides and proteins) Endothelium Vascular Hydroxymethylglutaryl-CoA Reductase Inhibitors Lipoprotein Blood vessel |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 298:E202-E209 |
| ISSN: | 1522-1555 0193-1849 |
| Popis: | Epidemiologic studies have shown that a low level of high-density lipoprotein (HDL) cholesterol is a risk factor for cardiovascular diseases. The purpose of this study was to determine the contribution of isolated low HDL cholesterol to endothelial function. Thirty-nine subjects with low HDL cholesterol who had no other cardiovascular risk factors were selected from the 5,417 participants from our population. We evaluated flow-mediated vasodilation (FMD) before and after 4 wk of treatment with the HMG-CoA reductase inhibitor pravastatin in 29 of the 39 subjects with isolated low HDL cholesterol. FMD was lower in the low-HDL-cholesterol group ( n = 29) than in the control group ( n = 29), whereas NTG-induced vasodilation was similar in the two groups. Pravastatin increased HDL cholesterol, urinary excretion of nitrite/nitrate, circulating levels of progenitor cells, and cell migration response to vascular endothelial growth factor in 15 subjects with low HDL cholesterol but not in 14 placebo control subjects. FMD increased in the pravastatin treatment group but not in the control group. NTG-induced vasodilation was similar before and after 4 wk of treatment in the two groups. Multiple regression analysis revealed that changes in HDL cholesterol, the number of progenitor cells, and migration of progenitor cells were independent predictors of augmentation of FMD with pravastatin. These findings suggest that low HDL cholesterol is an independent risk factor for endothelial dysfunction and that pravastatin improves endothelial function in individuals with isolated low HDL cholesterol through, at least in part, an increase in circulating progenitor cells. |
| Databáze: | OpenAIRE |
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