The synthesis rate of albumin decreases during laparoscopic surgery
| Autor: | Jan Wernerman, H. Barle, Anders Thörne, Peter J. Garlick, Pia Essén, Margaret A. McNurlan, Lars Hallstrom |
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| Rok vydání: | 2004 |
| Předmět: |
Laparoscopic surgery
Adult medicine.medical_specialty Physiology medicine.medical_treatment Liver protein Serum albumin Urology Phenylalanine Preoperative care Intraoperative Period Physiology (medical) Internal medicine Preoperative Care medicine Humans Laparoscopic cholecystectomy Serum Albumin biology business.industry Albumin Cholecystolithiasis General Medicine Middle Aged Endocrinology Cholecystectomy Laparoscopic biology.protein Cholecystectomy Female business |
| Zdroj: | Clinical physiology and functional imaging. 24(2) |
| ISSN: | 1475-0961 |
| Popis: | In previous studies, a decline in total liver protein synthesis during elective laparoscopic surgery has been observed. However, when albumin synthesis was measured in parallel no apparent influence of the procedure was detected. The aim of the present study was to specifically investigate the effect of a laparoscopic procedure on albumin synthesis. Female (n = 9) patients scheduled for elective laparoscopic cholecystectomy as a consequence of cholecystolithiasis were investigated. The fractional synthesis rate (FSR) of albumin was investigated twice in each patient, before and during surgery (2-3 h apart), employing L-[2H5]phenylalanine and gas chromatography mass spectrometry. The FSR of albumin decreased from 7.3 +/- 1.2% per day before surgery to 6.2 +/- 1.4% per day during the procedure (P |
| Databáze: | OpenAIRE |
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