Gamma Oscillations in Rat Hippocampal Subregions Dentate Gyrus, CA3, CA1, and Subiculum Underlie Associative Memory Encoding
| Autor: | Claire R. Galloway, Andrew Jones, Joseph R. Manns, Kaavya Mandi, John B. Trimper |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine CA3 Action Potentials Hippocampus Local field potential Hippocampal formation CA1 Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Memory Encoding (memory) Animals Theta Rhythm lcsh:QH301-705.5 CA1 Region Hippocampal object Physics Dentate gyrus synchrony Subiculum Content-addressable memory CA3 Region Hippocampal Rats Electrophysiology 030104 developmental biology lcsh:Biology (General) nervous system subiculum Dentate Gyrus gamma oscillations Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cell Reports, Vol 21, Iss 9, Pp 2419-2432 (2017) |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2017.10.123 |
| Popis: | Neuronal oscillations in the rat hippocampus relate to both memory and locomotion, raising the question of how these cognitive and behavioral correlates interact to determine the oscillatory network state of this region. Here, rats freely locomoted while performing an object-location task designed to test hippocampus-dependent spatial associative memory. Rhythmic activity in theta, beta, slow gamma, and fast gamma frequency ranges were observed in both action potentials and local field potentials (LFPs) across four main hippocampal subregions. Several patterns of LFP oscillations corresponded to overt behavior (e.g., increased dentate gyrus-CA3 beta coherence during stationary moments and CA1-subiculum theta coherence during locomotion). In comparison, slow gamma (~40 Hz) oscillations throughout the hippocampus related most specifically to object-location associative memory encoding rather than overt behavior. The results help to untangle how hippocampal oscillations relate to both memory and motion, and single out slow gamma oscillations as a distinguishing correlate of spatial associative memory. |
| Databáze: | OpenAIRE |
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