Preclinical evidences of aluminum-induced neurotoxicity in hippocampus and pre-frontal cortex of rats exposed to low doses
| Autor: | Luis Felipe Sarmiento, Rafael Monteiro Fernandes, Walessa Alana Bragança Aragão, Rafael Rodrigues Lima, Priscila Cunha Nascimento, Maria Elena Crespo-Lopez, Caroline Azulay Rodrigues, Cristiane Socorro Ferraz Maia, Marta Chagas Monteiro, Sabrina C. Cartágenes, Márcio Gonçalves Corrêa |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Memory Long-Term Health Toxicology and Mutagenesis 0211 other engineering and technologies Prefrontal Cortex Hippocampus 02 engineering and technology 010501 environmental sciences Hippocampal formation Inhibitory postsynaptic potential medicine.disease_cause 01 natural sciences Lipid peroxidation chemistry.chemical_compound Neurochemical Internal medicine medicine Aluminum Chloride Animals Rats Wistar Prefrontal cortex 0105 earth and related environmental sciences 021110 strategic defence & security studies business.industry Public Health Environmental and Occupational Health Neurotoxicity General Medicine medicine.disease Pollution Rats Oxidative Stress Endocrinology chemistry Neurotoxicity Syndromes business Oxidative stress Aluminum |
| Zdroj: | Ecotoxicology and Environmental Safety. 206:111139 |
| ISSN: | 0147-6513 |
| DOI: | 10.1016/j.ecoenv.2020.111139 |
| Popis: | Aluminum (Al) is a neurotoxicant agent implicated in several behavioral, neuropathological and neurochemical changes associated with cognitive impairments. Nevertheless, mechanisms of damage and safety concentrations are still very discussed. Thus, the main purpose of this study was to investigate whether two aluminum low doses were able to produce deleterious effects on cognition of adult rats, including oxidative stress in hippocampus and prefrontal cortex, two important areas for cognition. For this, thirty adult Wistar rats were divided into three groups: Al1 (8.3 mg/kg/day), Al2 (32 mg/kg/day) and Control (Ultrapure Water), in which all three groups received their solutions containing or not AlCl3 by intragastric gavage for 60 days. After the experimental period, the short- and long-term memories were assessed by the object recognition test and step-down inhibitory avoidance. After euthanizing, prefrontal cortex and hippocampus samples were dissected for Al levels measurement and evaluation of oxidative biochemistry. Only Al2 increased Al levels in hippocampal parenchyma significantly; both concentrations did not impair short-term memory, while long-term memory was affected in Al1 and Al2. In addition, oxidative stress was observed in prefrontal and hippocampus in Al1 and Al2. Our results indicate that, in a translational perspective, humans are subjected to deleterious effects of Al over cognition even when exposed to low concentrations, by triggering oxidative stress and poor long-term memory performance. |
| Databáze: | OpenAIRE |
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