Vascular endothelial growth factor expression in placenta of hypertensive disorder in pregnancy
| Autor: | Wirda Indah Farouk, Alfian Nurwardah, Abd Fuaat Azliana, Mohamad Razi Zainul-Rashid, Geok Chin Tan, Sabrina Florence Chandramaya, Yin Ping Wong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Vascular Endothelial Growth Factor A
0301 basic medicine Microbiology (medical) placenta lcsh:QR1-502 Syncytiotrophoblasts lcsh:Microbiology Pathology and Forensic Medicine Andrology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Placenta medicine lcsh:Pathology Humans Decidual cells reproductive and urinary physiology Retrospective Studies Microscopy Fetus 030219 obstetrics & reproductive medicine syncytiotrophoblasts vascular endothelial growth factor business.industry Hypertension Pregnancy-Induced General Medicine medicine.disease Trophoblasts Vascular endothelial growth factor Cross-Sectional Studies 030104 developmental biology medicine.anatomical_structure chemistry embryonic structures Hypertension immunohistochemistry Immunohistochemistry Female Cytotrophoblasts business lcsh:RB1-214 |
| Zdroj: | Indian Journal of Pathology and Microbiology, Vol 60, Iss 4, Pp 515-520 (2017) |
| ISSN: | 0377-4929 |
| Popis: | Introduction: Hypertensive disorder in pregnancy (HDP) represents the most common medical complication in pregnancy. It is the leading cause of maternal and perinatal mortality and morbidity. Vascular endothelial growth factor (VEGF) stimulates vascular endothelial cell growth, survival, and proliferation, and they are known to be expressed in human placenta. The aim of this study was to determine the VEGF expression in the placenta of hypertensive and normotensive patients. Materials and Methods: This is a retrospective, cross-sectional study from January 1, 2015 to December 31, 2015. A total of 30 placentae comprised of 15 hypertensive and 15 normotensive cases were assessed. VEGF expression in placenta was assessed by immunohistochemistry, and the number of syncytial knots was counted. Results: Our study showed an increased syncytial knot formation in the placenta of hypertensive mothers. VEGF expression was seen in syncytiotrophoblasts of 14 of the hypertensive cases (14/15, 93.3%), while only two of the normotensive cases were positive (2/15, 13.3%). There were no statistically significant differences in VEGF expression in other placenta cells, that is, cytotrophoblasts (P = 1.0), decidual cells (0.1394), maternal endothelial cells (0.5977), and fetal endothelial cells (P = 1.0). Conclusions: This study showed an increased number of syncytial knots is a consistent histological finding in the placenta of patient with HDP. VEGF expression was significantly increased in syncytiotrophoblasts in placenta of hypertensive group, and it could be used as a biomarker for hypertension. |
| Databáze: | OpenAIRE |
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