Thrombogenic Risk Induced by Intravascular Mesenchymal Stem Cell Therapy: Current Status and Future Perspectives
Autor: | Etienne Sokal, Xavier Stéphenne, Louise Coppin |
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Přispěvatelé: | UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique |
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
mesenchymal stem cells
anticoagulants business.industry Cell Mesenchymal stem cell Thrombosis General Medicine Review Mesenchymal Stem Cell Transplantation In vitro Complement system cell- and tissue-based therapy Thromboplastin Clinical trial Tissue factor medicine.anatomical_structure lcsh:Biology (General) Coagulation In vivo medicine Cancer research Humans business lcsh:QH301-705.5 Blood Coagulation |
Zdroj: | Cells Cells, Vol. 8, no. 10, p. 1160 [1-16] (2019) Cells, Vol 8, Iss 10, p 1160 (2019) |
ISSN: | 2073-4409 |
Popis: | Mesenchymal stem cells (MSCs) are currently studied and used in numerous clinical trials. Nevertheless, some concerns have been raised regarding the safety of these infusions and the thrombogenic risk they induce. MSCs express procoagulant activity (PCA) linked to the expression of tissue factor (TF) that, when in contact with blood, initiates coagulation. Some even describe a dual activation of both the coagulation and the complement pathway, called Instant Blood-Mediated Inflammatory Reaction (IBMIR), explaining the disappointing results and low engraftment rates in clinical trials. However, nowadays, different approaches to modulate the PCA of MSCs and thus control the thrombogenic risk after cell infusion are being studied. This review summarizes both in vitro and in vivo studies on the PCA of MSC of various origins. It further emphasizes the crucial role of TF linked to the PCA of MSCs. Furthermore, optimization of MSC therapy protocols using different methods to control the PCA of MSCs are described. |
Databáze: | OpenAIRE |
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