ANTIBACDUS-PAN: Antibacterial Utilization among Adult Patients Before and During COVID-19 Pandemic within 12-Months Period: A Tertiary Hospital Pharmacoepidemiology Study
| Autor: | Ege Anil Ucar, Mehmet Batuhan Karakus, Mustafa Guldan, Selin Merve Sahin, Uluman Sisman, Arzu Baygul, Sinem Ezgi Gulmez |
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| Přispěvatelé: | Uçar, Ezgi Anıl, Karakuş, Batuhan Mehmet, Güldan, Mustafa, Şahin, Selin Merve, Şişman, Uluman, Baygül, Arzu (ORCID 0000-0003-0392-6709 & YÖK ID 272290), Gülmez, Sinem Ezgi (ORCID 0000-0001-8815-9128 & YÖK ID 281312), Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Infectious Diseases and Clinical Microbiology |
| ISSN: | 2667-646X |
| DOI: | 10.36519/idcm.2022.100 |
| Popis: | Objective: irrational use of antibacterials is a concern during the COVID-19 pandemic. Hospital pharmacoepidemiology studies are important for evaluating the rational use of medicines, especially antibacterials, during pandemics. Defined daily doses (DDD) and drug utilization 90% (DU90%) are established methods for the evaluation of drug utilization. We aimed to evaluate antibacterial utilization in a tertiary hospital setting at Koç University Hospital (KUH). Materials and methods: this cross-sectional, descriptive study was retrospectively conducted with data extracted from KUH Inpatient Electronic Order System (CP) and was carried out for a period of one year. Antibacterial utilization of adult (aged ? 18 years) inpatients, who were prescribed at least one type of systemic antibacterial (ATC code J01), was evaluated using the recommended parameter DDD/100 admission and compared between 6 months before COVID-19 and during COVID-19 periods. March 11, 2020, the very first COVID-19 diagnosed case in Turkey, was set as the cutoff date of the 6-month period for the selection of the compared antibacterials using the DU90% method. Results: finally, 3280 of 5942 and 2605 of 4942 prescriptions for pre-COVID-19 and COVID-19 periods were included, respectively. Antibacterial utilization according to DDD/100 admissions increased from 193.96 to 201.26 DDD/100 admissions after the initiation of COVID-19 pandemic. The most utilized antibacterials were piperacillin and enzyme inhibitors in pre-COVID-19 period, whereas meropenem was utilized the most during COVID-19 period. Azithromycin utilization increased by 656.24%, whereas clarithromycin utilization decreased by 52.12%. Antibacterials were utilized most in general surgery department, with an increase of 17.57%. Conclusion: there is an increase in antibacterial utilization in KUH during COVID-19 pandemic, especially reserved antibacterials, which is a concern for antibacterial resistance. NA |
| Databáze: | OpenAIRE |
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