Clinicopathological and prognostic significance of myofibrillogenesis regulator-1 protein expression in pancreatic ductal adenocarcinoma
| Autor: | Sai-Min Dai, Zi-Jian Guo, Yong Zhang, Changyong Zhao, Jun-Jing Zhou |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Pathology Pancreatic ductal adenocarcinoma Multivariate analysis Gene Expression Muscle Proteins Kaplan-Meier Estimate Protein expression Disease-Free Survival Antigens CD Internal medicine medicine Humans Survival analysis Aged Neoplasm Staging business.industry Proportional hazards model General Medicine Middle Aged Cadherins Prognosis Myofibrillogenesis regulator 1 Pancreatic Neoplasms Lymphatic Metastasis Multivariate Analysis Biomarker (medicine) Immunohistochemistry Female business Carcinoma Pancreatic Ductal |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 34(5) |
| ISSN: | 1423-0380 |
| Popis: | Myofibrillogenesis regulator-1 (MR-1) expression was detected in different malignancies and is associated with poor prognosis. However, its role in pancreatic ductal adenocarcinoma (PDAC) has not been fully elucidated. Thus, the aim of this study was to investigate the association of MR-1 expression with clinicopathologic features and prognosis in patients with PDAC. Immunohistochemistry was performed to investigate the protein expression of MR-1 and epithelial (E)-cadherin in 87 patients with PDAC. Results showed that MR-1 expression was correlated with histologic grade, tumor stage, and lymph node metastasis (all P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink