Effects of adrenalectomy and glucocorticoid receptor antagonist, RU38486, on pituitary growth hormone-releasing hormone receptor gene expression in rats
| Autor: | Koji Murao, Jiro Takahara, Michio Niimi, Tomoyo Ohyama, Hidemi Ohye, Makoto Sato |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Receptors Neuropeptide medicine.medical_specialty Physiology medicine.medical_treatment Polymerase Chain Reaction Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Receptors Glucocorticoid Endocrinology Glucocorticoid receptor Receptors Pituitary Hormone-Regulating Hormone Internal medicine medicine Animals RNA Messenger Rats Wistar Receptor Chemistry Adrenalectomy Antiglucocorticoid Growth hormone–releasing hormone Growth hormone secretion Rats Mifepristone Gene Expression Regulation Hormone receptor Growth Hormone Pituitary Gland Corticosterone Glucocorticoid medicine.drug |
| Zdroj: | Peptides. 19:1063-1067 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/s0196-9781(97)00472-5 |
| Popis: | We examined the effects of adrenalectomy and a glucocorticoid receptor antagonist, RU38486, on pituitary GH-releasing hormone (GRH) receptor gene expression in rats. GRH receptor mRNA levels were significantly decreased in adrenalectomized rats and replacement of dexamethasone reversed the decrease to normal. GH secretion was inhibited by adrenalectomy, whereas dexamethasone replacement failed to restore the impaired GH secretion. A high dose of RU38486 had an agonistic effect on GRH receptor mRNA levels. These results suggest that endogenous glucocorticoid is necessary for normal expression of pituitary GRH receptor mRNA in rats. |
| Databáze: | OpenAIRE |
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