Cumulative exposure to solar ultraviolet A & B increases apoptosis of peripheral blood cutaneous lymphocyte antigen (CLA)+ T-Lymphocytes in outdoor workers
| Autor: | Isaak Effendy, Saut Sahat Pohan, Widodo J. Pudjirahardjo, Afif Nurul Hidayati |
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| Rok vydání: | 2018 |
| Předmět: |
integumentary system
business.industry medicine.medical_treatment bcl-2 apoptosis food and beverages Cumulative Exposure cla+ t-lymphocyte Immunosuppression Inflammation T lymphocyte lcsh:RL1-803 medicine.disease Phototype Immune system Apoptosis bax Immunology lcsh:Dermatology medicine Skin cancer medicine.symptom business solar uva-uvb |
| Zdroj: | JDVI (Journal of General Procedural Dermatology & Venereology Indonesia), Vol 3, Iss 1, Pp 11-20 (2018) |
| ISSN: | 2460-7991 |
| Popis: | Background: Exposure to ultraviolet A & B (UVA-UVB) plays a role in the survival of human life, but it may cause negative effects, such as immunosuppression and skin cancer. The effect of solar UVA-UVB exposure on apoptosis (Bax/Bcl-2 ratio) of peripheral blood cutaneous lymphocyte antigen (CLA)+ T-lymphocyte; the immune competent cells in the skin, has not been investigated. Apoptosis of peripheral blood CLA+ Tlymphocyte affects its function; which serves as the skin's resistance and is involved in infectious diseases, skin inflammation, and malignancies. This study observed the effect of solar UVA-UVB to apoptosis (Bax/Bcl2 ratio) of peripheral blood CLA+ T-lymphocytes. Methods: An observational cohort study of 37 male outdoor workers (caddies on the golf course) and 33 indoor workers in Surabaya, aged 20-45 years, with skin phototype IV/V. Measurement of solar UVA-UVB doses received by the subjects was conducted for 2, 4, and 8 weeks. Examination of Bax and Bcl-2 of peripheral blood CLA+ T-lymphocyte was conducted at the beginning of the study, after 4 and 8 weeks. Results: The average dose of solar UVA-UVB for 8 weeks received by outdoor workers was 12450.51±3948.81 (J/m2 ) and that by indoor workers was 1793.97±1518.46 (J/m2 ). Exposure to solar UVAUVB leads to the increase of apoptosis (Bax/Bcl-2 ratio) of peripheral blood CLA+ T-lymphocytes (p=0.003). Conclusion: Cumulative exposure to solar UVA-UVB radiation in high-dose or received within 8 weeks resulted in the increase in apoptosis of peripheral blood CLA+ T-lymphocytes. Keywords : solar UVA-UVB, CLA + T Lymphocyte, Bax, Bcl-2, apoptotic . |
| Databáze: | OpenAIRE |
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