Twenty-Year Outcomes after Breast-Conserving Surgery and Definitive Radiotherapy for Mammographically Detected Ductal Carcinoma In Situ
| Autor: | Maha S. Jawad, Hong Ye, Frank A. Vicini, Peter Y. Chen, Neal S. Goldstein, Chirag Shah, Alvaro Martinez, Simona F. Shaitelman, J. Ben Wilkinson, Pamela Benitez, Larry L. Kestin |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Oncology medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Mastectomy Segmental Breast cancer Risk Factors Internal medicine Breast-conserving surgery Humans Medicine Mammography Neoplasm Invasiveness skin and connective tissue diseases Survival rate Mastectomy Aged Neoplasm Staging Aged 80 and over medicine.diagnostic_test business.industry Lumpectomy Middle Aged Ductal carcinoma Prognosis medicine.disease Combined Modality Therapy Survival Rate Radiation therapy Carcinoma Intraductal Noninfiltrating Female Radiotherapy Adjuvant Surgery Radiology Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Annals of Surgical Oncology. 19:3785-3791 |
| ISSN: | 1534-4681 1068-9265 |
| DOI: | 10.1245/s10434-012-2412-5 |
| Popis: | Management of mammographically detected ductal carcinoma in situ (DCIS) at a single institution was reviewed to determine long-term clinical outcomes after treatment with breast-conserving therapy (BCT). Data from all patient-cases with DCIS who received BCT between 1980 and 1993 were reviewed. Patient demographics and pathologic factors were analyzed for their effect on outcomes, including ipsilateral breast tumor recurrence (IBTR) and survival. BCT included breast-conserving surgery followed by external-beam radiotherapy to the whole breast, with 86 % of patients receiving a lumpectomy cavity boost. The median dose to the whole breast was 50 Gy and 60.4 Gy to the lumpectomy cavity. A total of 129 cases were evaluated; the median follow-up was 19.3 years. Twenty-one patients developed an ipsilateral breast tumor recurrence (IBTR), 76.2 % of which were invasive (n = 16). Fourteen recurrences (66 %) were within the same breast quadrant (true recurrence), while an additional 7 cases developed an IBTR elsewhere in the breast. True recurrences were more prevalent in women |
| Databáze: | OpenAIRE |
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