Frontotemporal dementia
| Autor: | Jonathan A Knibb, Christopher M Kipps, John R Hodges |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Diagnostic Imaging
0303 health sciences Ubiquitin Brain Diagnosis Differential 03 medical and health sciences Aphasia Primary Progressive 0302 clinical medicine Tauopathies Neurology Humans Dementia Genetic Predisposition to Disease Neurology (clinical) 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Current Opinion in Neurology. 19:565-571 |
| ISSN: | 1350-7540 |
| Popis: | The syndromes of frontotemporal lobar degeneration are increasingly recognized as an important cause of early-onset dementia. Diagnostic consensus criteria have now been established for almost a decade, and form the framework for its clinical classification. While these criteria remain useful, a growing body of evidence suggests that revisions may be necessary to improve their validity and applicability.In each individual syndrome, the core features are not uniformly present, and criteria that are currently used to exclude a condition, such as impaired episodic memory, are often present. Imaging, however, may warrant increased diagnostic prominence, particularly for diagnosis in semantic dementia and prognosis in behavioural syndromes. There is clinical and pathological overlap between the syndromes, but the clinical distinction between progressive nonfluent aphasia and semantic dementia is strengthening. Several series have refined our understanding of the correspondence between clinical syndromes and histopathological subtype: strong for tau-negative, ubiquitin-positive forms and more variable for tau-positive forms, yet prospective studies are still rare. The influence of genetic factors varies substantially across the syndromes.Further research should aim to integrate detailed clinical, radiological, pathological and genetic information. |
| Databáze: | OpenAIRE |
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