Thermal treatment stimulus on erythrocyte compatibility and hemostatic behavior of one-dimensional bioactive nanostructures
| Autor: | Riju Chandran R, Chitra Shivalingam, Balakumar Subramanium, Bargavi Purushothaman |
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| Rok vydání: | 2020 |
| Předmět: |
Ceramics
Materials science Erythrocytes Hot Temperature Biocompatibility Annealing (metallurgy) Surface Properties 0206 medical engineering Biomedical Engineering chemistry.chemical_element Biocompatible Materials 02 engineering and technology Thermal treatment Calcium Fibrin Phase Transition law.invention Nanomaterials Biomaterials law Materials Testing Humans Hemostasis biology Metals and Alloys 021001 nanoscience & nanotechnology 020601 biomedical engineering Nanostructures chemistry Chemical engineering Bioactive glass Ceramics and Composites biology.protein Liberation 0210 nano-technology |
| Zdroj: | Journal of biomedical materials research. Part AREFERENCES. 108(11) |
| ISSN: | 1552-4965 |
| Popis: | This study identifies the role and significance of heat treatment parameters on blood compatibility and hemostatic performances. Bioactive nanomaterials step annealed at 550 and 600°C enhances the biocompatibility due to the liberation of nitrate content. This also develops the anisotropic structures such as needle-like and rod-like appearances that positively improve the erythrocyte compatibility. Different stable crystalline phases such as NaCaPO4 , Na2 Ca2 Si3 O9 , and Na1.8 Ca1.1 Si6 O14 were observed for all the bioactive materials, whereas in the case of 800°C, phase transition of Na3 CaPSiO7 was perceived along with P2 O5 . Alternatively, morphology varied from cubical (600°C) to rod-like (step annealing) and further turned toward flake-like (800°C) structures. Step-annealing process decomposed the nitrate groups as well as maintained the glass network without altering the crystalline phases. As a result, bioactive nanomaterials subjected to step annealing at 550°C along with 600°C exhibited superior compatibility with erythrocytes. Bioglass heat treated at 800°C revealed incredible blood clotting efficacy, in which Ca2+ ions initiated the thrombotic effect, blood components were concentrated due to the effect of calcium, and enhances the hemostatic performance. Bioactive glass annealed below 800°C facilitates the biocompatibility, subsequently encourage bone ingrowths at in vivo. Bioglass-800°C inspired the fibrin formation and induced clot as a hemostat to control hemorrhage. |
| Databáze: | OpenAIRE |
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