Increase in lymphocyte subsets following treatment of HIV-associated neutropenia with granulocyte colony-stimulating factor
| Autor: | Raphael B. Stricker, Billi Goldberg |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Neutropenia medicine.drug_class Lymphocyte Immunology HIV Infections Granulocyte CD8-Positive T-Lymphocytes Immunostimulant Pathology and Forensic Medicine White blood cell medicine Immunology and Allergy Cytotoxic T cell Humans Lymphocyte Count Leukopenia business.industry Granulocyte-Macrophage Colony-Stimulating Factor medicine.disease Lymphocyte Subsets Recombinant Proteins Granulocyte colony-stimulating factor medicine.anatomical_structure medicine.symptom business |
| Zdroj: | Clinical immunology and immunopathology. 79(2) |
| ISSN: | 0090-1229 |
| Popis: | Recombinant human granulocyte colony-stimulating factor (G-CSF) has been used to treat neutropenia in patients with cancer and HIV disease. Since lymphocyte counts have been reported to increase with G-CSF therapy, we studied the effect of G-CSF on lymphocyte subsets in HIV-infected patients. Six patients with HIV-associated neutropenia were treated with G-CSF and had significant increases in white blood cell counts. G-CSF induced a significant rise in total lymphocytes, total T-cells, CD8 T-cells, and natural killer cells. A smaller but statistically significant increase in CD4 T-cells and cytotoxic CD8 T-cells was also noted. We conclude that G-CSF has the ability to raise lymphocyte subset levels in patients with HIV disease. The potential immunologic benefit of G-CSF therapy merits further investigation. |
| Databáze: | OpenAIRE |
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