Myocardial Infarction and Atrial Fibrillation
| Autor: | Walter P. Abhayaratna, Kurt C. Roberts-Thomson, Dennis H. Lau, Han S. Lim, Anthony G. Brooks, Pawel Kuklik, Matthew I. Worthley, David A. Saint, Muayad Alasady, Nicholas J. Shipp, D. Barlow, Prashanthan Sanders |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Acute coronary syndrome
medicine.medical_specialty Time Factors Myocardial ischemia Refractory Period Electrophysiological Myocardial Infarction Ischemia Action Potentials Ventricular Function Left Ventricular Dysfunction Left Atrial Pressure Animal model Heart Rate Risk Factors Physiology (medical) Internal medicine Atrial Fibrillation Animals Medicine Heart Atria cardiovascular diseases Myocardial infarction Sheep Ventricular function business.industry Atrial fibrillation medicine.disease Disease Models Animal cardiovascular system Cardiology Atrial Function Left Electrophysiologic Techniques Cardiac Cardiology and Cardiovascular Medicine business Heart atrium |
| Zdroj: | Circulation: Arrhythmia and Electrophysiology. 6:738-745 |
| ISSN: | 1941-3084 1941-3149 |
| Popis: | Background— Myocardial infarction (MI) is associated with the development of atrial fibrillation (AF). We aimed to characterize the atrial abnormalities because of MI and determine the role of ischemia to the AF substrate. Methods and Results— Forty-four sheep were studied. MI was induced by occlusion of the left circumflex artery (LCX) or left anterior descending artery (LAD). Excluding 11 with fatal arrhythmias, equal groups of animals (LCX; LAD; and sham-operated) underwent sequential electrophysiology study for 45 minutes to determine atrial effective refractory periods, conduction velocity, conduction heterogeneity index, and AF inducibility. Postmortem evaluation was performed with 2,3,5 triphenyl tetrazolium chloride staining. MI resulted in greater left ventricular dysfunction ( P P P P P P P P P P P P Conclusions— Left ventricular infarction, which is known to result in atrial stretch, hemodynamic change, and neurohumoral activation, contributes partially to the atrial abnormalities in MI. Atrial ischemia/infarction results in greater atrial electrophysiological changes and propensity for AF forming the dominant substrate for AF in MI. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|