A Prospective, Matched Comparison Study of SUV Measurements From Time-of-Flight Versus Non-Time-of-Flight PET/CT Scanners
| Autor: | Andrei Iagaru, Holly M. Thompson, Rie von Eyben, Amir Barkhodari, Ryogo Minamimoto, Mehran Jamali |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Scanner Pooling Statistical power 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Neoplasms Positron Emission Tomography Computed Tomography Medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Positron Emission Tomography-Computed Tomography PET-CT business.industry Reproducibility of Results General Medicine Middle Aged Time of flight 030220 oncology & carcinogenesis Ct scanners Comparison study Female Nuclear medicine business |
| Zdroj: | Clinical nuclear medicine. 41(7) |
| ISSN: | 1536-0229 |
| Popis: | As quantitative F-FDG PET numbers and pooling of results from different PET/CT scanners become more influential in the management of patients, it becomes imperative that we fully interrogate differences between scanners to fully understand the degree of scanner bias on the statistical power of studies.Participants with body mass index (BMI) greater than 25, scheduled on a time-of-flight (TOF)-capable PET/CT scanner, had a consecutive scan on a non-TOF-capable PET/CT scanner and vice versa. SUVmean in various tissues and SUVmax of malignant lesions were measured from both scans, matched to each subject. Data were analyzed using a mixed-effects model, and statistical significance was determined using equivalence testing, with P0.05 being significant.Equivalence was established in all baseline organs, except the cerebellum, matched per patient between scanner types. Mixed-effects method analysis of lesions, repeated between scan types and matched per patient, demonstrated good concordance between scanner types.Patients could be scanned on either a TOF or non-TOF-capable PET/CT scanner without clinical compromise to quantitative SUV measurements. |
| Databáze: | OpenAIRE |
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