The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus–pituitary–adrenal axis
| Autor: | Weijie Wang, Li Wang, Gang Wang, Yingcong Yu, Cong Pang, Jianchun Pan, Jiejin Zhu, Han-Ting Zhang, Meixi Zhang, Ling Chen, Lichao Chen, Fan Wu, Weihong Lv, Lianshu Ding, Liang Cao, Ying Xu |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System Imipramine medicine.medical_specialty Pituitary-Adrenal System Hippocampus Brain damage Brain Ischemia Rats Sprague-Dawley Brain ischemia Random Allocation Cellular and Molecular Neuroscience Neurotrophic factors Internal medicine Stilbenes medicine Animals Post-stroke depression Stroke Pharmacology Depressive Disorder Dose-Response Relationship Drug Adrenal gland Infarction Middle Cerebral Artery medicine.disease Antidepressive Agents Frontal Lobe Disease Models Animal Neuroprotective Agents Endocrinology medicine.anatomical_structure nervous system Resveratrol Hypothalamus medicine.symptom Psychology Neuroscience |
| Zdroj: | Neuropharmacology. 97:447-456 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/j.neuropharm.2015.04.017 |
| Popis: | Post-stroke depression (PSD) occurs about 40% among all stroke survivors, but the effective pharmacotherapy is inadequately understood. The present study investigated the effects of a natural polyphenol trans-resveratrol (RES) on behavioral changes after middle cerebral artery occlusion (MCAO) and examined what its molecular targets may be. RES was shown to decrease the infarct size and neurological scores after MCAO, suggesting the amelioration of brain damage and motor activity. RES also reversed the depressive-like behaviors 13 days after MCAO, both in the forced swimming and sucrose consumption tests. Moreover, MCAO-induced series abnormalities related to depressive-like behaviors, such as an abnormal adrenal gland weight to body weight ratio, an increased expression of the corticotropin-releasing factor (CRF) in the frontal cortex, hippocampus and hypothalamus, the differential expression of glucocorticoid receptor (GR) in these three brain regions, and a decreased brain-derived neurotrophic factor (BDNF) level, were ameliorated after treatment with increasing doses of RES at 10, 20 and 40 mg/kg via gavage. These findings provide compelling evidence that RES protects the brain against focal cerebral ischemia-induced injury, but most of all is its antidepressant-like effect on PSD, which might at least in part be mediated by regulation of hypothalamus-pituitary-adrenal axis function. |
| Databáze: | OpenAIRE |
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