Locoregionally advanced oral cavity cancer: A propensity-score matched analysis on overall survival with emphasis on the impact of adjuvant radiotherapy
| Autor: | Aidnag Z. Diaz, Jacob Y. Shin, Ja Kyoung Yoon, Aaron K. Shin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Adolescent medicine.medical_treatment Disease Oral cavity 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Overall survival medicine Humans 030212 general & internal medicine Propensity Score Aged Proportional Hazards Models Retrospective Studies Aged 80 and over Adjuvant radiotherapy Proportional hazards model business.industry Cancer Middle Aged medicine.disease Survival Rate Otorhinolaryngology 030220 oncology & carcinogenesis Propensity score matching Carcinoma Squamous Cell Female Mouth Neoplasms Radiotherapy Adjuvant business Adjuvant |
| Zdroj: | Headneck. 40(9) |
| ISSN: | 1097-0347 |
| Popis: | Background The purpose of this study was to determine the impact of adjuvant radiotherapy (RT) in locoregionally advanced oral cavity cancer. Methods Data were extracted from the National Cancer Data Base, of which overall survival (OS) is the only outcome variable available. The chi-square test and Cox regression models were used. Results A total of 6654 patients were identified. The utilization of adjuvant RT has increased over time. A propensity matched cohort included 3946 patients, exactly one-half of whom received adjuvant RT. Independent predictors associated with receipt of adjuvant RT included age, Charlson/Deyo comorbidity score, extracapsular extension, surgical margins, and T and N classifications. On multivariable analysis, adjuvant RT remained an independent prognosticator for OS. Conclusion Receipt of adjuvant RT is a prognostic factor associated with improved OS, its utilization has increased over time, and it should be considered for clinically suitable patients who have undergone resection for the disease. |
| Databáze: | OpenAIRE |
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