The importance of alcohol misuse, malnutrition and genetic susceptibility on brain growth and plasticity
| Autor: | Hugh D. Gurling, Allan D. Thomson, Irene Guerrini |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Alcohol Drinking Cognitive Neuroscience Physiology Brain damage Behavioral Neuroscience Alcohol and health Pregnancy Internal medicine Genetic predisposition medicine Animals Humans Maternal-Fetal Exchange Fetus Neuronal Plasticity Malnutrition Brain medicine.disease B vitamins Neuropsychology and Physiological Psychology Endocrinology Female medicine.symptom Psychology Social behavior |
| Zdroj: | Neuroscience & Biobehavioral Reviews. 31:212-220 |
| ISSN: | 0149-7634 |
| Popis: | The "dyad: alcoholic mother and foetus" is a very complex entity in which several elements such as genes, metabolism, diet, drugs and social habits play a role at different stages in the development of the fetal brain damage. The literature on the effects of alcohol consumption on the developing brain is extensive but very few evidences have been reported regarding the combined neurotoxic effects of poor nutrition and alcohol consumption. The consequences of ethanol intake alone or combined with poor maternal nutrition appear to be severe and life-long. Alcohol exerts its neurotoxic effects on the developing brain directly by acting on fetal brain tissues, and indirectly either by interfering with placental physiology or by impairing the mother's physiology. Alcohol misuse in pregnancy is also frequently associated with other conditions that can potentially increase the brain damage such as poor nutrition and smoking. This article reviews the effects of poor nutrition and alcohol misuse during pregnancy on the development of the fetal brain and discusses the cumulative effects of these two environmental factors and their interaction with maternal and fetal genetic make-ups. |
| Databáze: | OpenAIRE |
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