Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network
| Autor: | William Oh, David K. Stevenson, Barbara J. Stoll, Charles R. Bauer, Lu-Ann Papile, Seetha Shankaran, Jon E. Tyson, Richard A. Ehrenkranz, Avroy A. Fanaroff, S B Korones, Tavia Gordon, Linda L. Wright, Edward F. Donovan, Joel Verter, James A. Lemons |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Birth weight Sepsis Cohort Studies Risk Factors Cause of Death medicine Humans Infant Very Low Birth Weight Prospective Studies Registries Age of Onset business.industry Mortality rate Incidence Candidiasis Infant Newborn Gestational age Bacterial Infections Length of Stay medicine.disease Low birth weight Intraventricular hemorrhage Bronchopulmonary dysplasia Pediatrics Perinatology and Child Health Necrotizing enterocolitis Multivariate Analysis Female medicine.symptom business |
| Zdroj: | The Journal of pediatrics. 129(1) |
| ISSN: | 0022-3476 |
| Popis: | OBJECTIVE: Late-onset sepsis (occurring after 3 days of age) is an important problem in very low birth weight (VLBW) infants. To determine the current incidence of late-onset sepsis, risk factors for disease, and the impact of late-onset sepsis on subsequent hospital course, we evaluated a cohort of 7861 VLBW (401 to 1500 gm) neonates admitted to the 12 National Institute of Child Health and Human Development (NICHD) Neonatal Research Network centers during a 32-month period (1991 to 1993). METHODS: The NICHD Neonatal Research Network maintains a prospectively collected registry of all VLBW neonates cared for at participating centers. Data from this registry were analyzed retrospectively. RESULTS: Of 6911 infants who survived beyond 3 days, 1696 (25%) had one or more episodes of blood culture-proven sepsis. The vast majority of infections (73%) were caused by gram-positive organisms, with coagulase-negative staphylococci accounting for 55% of all infections. Rate of infection was inversely related to birth weight and gestational age. Complications of prematurity associated with an increased rate of infection included intubation, respiratory distress syndrome, prolonged ventilation, bronchopulmonary dysplasia, patent ductus arteriosus, severe intraventricular hemorrhage, and necrotizing enterocolitis. Among infants with bronchopulmonary dysplasia, those with late-onset sepsis had a significantly longer duration of mechanical ventilation (45 vs 33 days; p |
| Databáze: | OpenAIRE |
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