Development and evaluation of paclitaxel nanoemulsion for cancer therapy
| Autor: | Sami Nazzal, Sandeep Pallerla, Sara Shakhwar, Rana Darwish, Ahmed Abu Fayyad, Mohammad M. Kamal |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Paclitaxel
medicine.medical_treatment Cancer therapy Pharmaceutical Science Antineoplastic Agents 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy Polyethylene Glycols 03 medical and health sciences chemistry.chemical_compound Vitamin E-TPGS Surface-Active Agents 0302 clinical medicine Cell Line Tumor medicine Humans Vitamin E heterocyclic compounds Tocopherol Chromans business.industry food and beverages General Medicine 021001 nanoscience & nanotechnology Pancreatic Neoplasms chemistry Solubilization lipids (amino acids peptides and proteins) Emulsions 0210 nano-technology business |
| Zdroj: | Pharmaceutical development and technology. 25(4) |
| ISSN: | 1097-9867 |
| Popis: | Tocosol™ is a tocopherol-based paclitaxel (PTX) nanoemulsion consisting of α-tocopherol (α-T) isomer of vitamin E as a solubilizer and vitamin E TPGS as the primary emulsifier. Despite its positive attributes in early clinical studies, it failed the pivotal phase III clinical trials. The long-term goal of this work was to reformulate Tocosol™. In this study, Tocosol™ formulation was optimized by replacing the α-T isomer with the more pharmacological active isomer γ-tocotrienol (γ-T |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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