Regulation of insulin-like growth factor-binding protein-3 ternary complex in feline diabetes mellitus

Autor:	D B Church, Moira S. Lewitt, A D J Watson, Susan J. Hazel, K. Tan, S E Powell
Rok vydání:	2000
Předmět:	medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Blotting Western Radioimmunoassay Cat Diseases Insulin-like growth factor-binding protein Insulin-like growth factor Endocrinology Insulin-Like Growth Factor II Predictive Value of Tests Diabetes mellitus Internal medicine Diabetes Mellitus medicine Animals Insulin-Like Growth Factor I Ternary complex Glycoproteins CATS biology Fissipedia medicine.disease biology.organism_classification Blot Insulin-Like Growth Factor Binding Protein 3 Case-Control Studies Acromegaly Cats biology.protein Electrophoresis Polyacrylamide Gel Carrier Proteins
Zdroj:	Scopus-Elsevier
ISSN:	1479-6805 0022-0795
Popis:	The 140 kDa ternary complex of insulin-like growth factor-binding protein-3 (IGFBP-3), IGFs and an acid-labile subunit (ALS) has previously been shown to be decreased in diabetes mellitus in humans and rats. We have studied IGF-I levels and ternary complex formation in normal and diabetic cats. Total IGF-I concentrations, measured by RIA using des(1-3)-IGF-I as tracer were (+/-s.e.m.) 54+/-13 nmol/l in eight normal and 227+/-57 nmol/l in eight diabetic cats (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338321897d293c8e8f8fb67c5d4bb383 https://doi.org/10.1677/joe.0.1660021 Zobrazit plný text záznamu