Deregulated expression of fat and muscle genes in B-cell chronic lymphocytic leukemia with high lipoprotein lipase expression

Autor:	Oswald Wagner, Martin Bilban, T Scharl, Birgit Kainz, Alexander Kröber, Christoph C. Zielinski, A. Gaiger, Stephan Stilgenbauer, Medhat Shehata, E. Porpaczy, Michael Auer, T Woelfel, Daniel Heintel, Ulrich Jäger, Vincent J. Carey, Winfried F. Pickl
Rok vydání:	2006
Předmět:	Cancer Research Chronic lymphocytic leukemia Immunoglobulin Variable Region Biology Gene Expression Regulation Enzymologic GTP Phosphohydrolases Cohort Studies Dystrophin Gene expression medicine Humans RNA Messenger Gene Regulation of gene expression Lipoprotein lipase Gene Expression Regulation Leukemic Reverse Transcriptase Polymerase Chain Reaction Microarray analysis techniques Gene Expression Profiling Fatty Acids digestive oral and skin physiology nutritional and metabolic diseases Hematology medicine.disease Leukemia Lymphocytic Chronic B-Cell Molecular biology Gene expression profiling Cytoskeletal Proteins Lipoprotein Lipase Leukemia Oncology Biochemistry Mutation lipids (amino acids peptides and proteins) Immunoglobulin Heavy Chains Septins
Zdroj:	Leukemia. 20:1080-1088
ISSN:	1476-5551 0887-6924
Popis:	Lipoprotein lipase (LPL) is a prognostic marker in B-cell chronic lymphocytic leukemia (B-CLL) related to immunoglobulin V(H) gene (IgV(H))mutational status. We determined gene expression profiles using Affymetrix U133A GeneChips in two groups of B-CLLs selected for either high ('LPL+', n=10) or low ('LPL-', n=10) LPL mRNA expression. Selected genes were verified by real-time PCR in an extended patient cohort (n=42). A total of 111 genes discriminated LPL+ from LPL- B-CLLs. Of these, the top three genes associated with time to first treatment were Septin10, DMD and Gravin (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3383124c5ad22a739e80b8f186307944 https://doi.org/10.1038/sj.leu.2404220 Zobrazit plný text záznamu Plný text ve formátu PDF