Diagnosis of optic nerve head drusen using enhanced depth imaging optical coherence tomography
| Autor: | Naon Kim-Yeon, Laura Modamio-Gardeta, Sofia De Manuel-Triantafilo, Mercedes Leal-González, Julio Yangüela, Pablo Gili |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Optic Disk
Pseudopapilloedema Drusen Optic disc oedema 03 medical and health sciences 0302 clinical medicine Optical coherence tomography medicine Humans medicine.diagnostic_test business.industry Optic Disk Drusen General Medicine medicine.disease Predictive value Optic disc drusen Ophthalmology Cross-Sectional Studies 030221 ophthalmology & optometry Optic nerve Enhanced depth imaging business Nuclear medicine 030217 neurology & neurosurgery Tomography Optical Coherence Papilledema |
| Zdroj: | European journal of ophthalmology. 31(6) |
| ISSN: | 1724-6016 |
| Popis: | Purpose: To evaluate the efficacy of Enhanced Depth Imaging Optical Coherence Tomography (EDI-OCT) in differentiating between optic nerve head drusen (ONHD) and optic disc oedema (ODE). Methods: This was a cross-sectional study of 140 patients: 83 patients with ONHD (49 hidden and 34 visible), 20 patients with pseudopapilloedema (without drusen), and 37 patients with ODE. EDI-OCT of the optic nerve was performed, selecting one high-resolution line from the HD 5-line raster protocol. Two observers blindly evaluated the presence of a hyporeflective core surrounded by a hyperreflective margin or border. The sensitivity, specificity, predictive values and posttest probability were evaluated as well as the inter-observer agreement (k). Results: EDI-OCT demonstrated a sensitivity of 92% (95% CI: 83%–96%), a specificity of 96% (95% CI: 87%–99%), with a positive predictive value of 97% and a negative predictive value of 89%. The inter-observer agreement was as remarkable as k = 0.8985 (95% CI 0.8252–0.9718). A positive EDI OCT increases the posttest probability to 97% (95% CI: 91%–99%); when negative, the posttest probability is reduced to 12% (95% CI: 6%–21%). Conclusion: EDI-OCT allowed for differentiation between ONHD and ODE with high sensitivity and specificity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|