CD1d expression is higher in chronic lymphocytic leukemia patients with unfavorable prognosis
Autor: | Agnieszka Bojarska-Junak, Justyna Woś, Waldemar Tomczak, Iwona Hus, Paweł Czubak, Jacek Roliński, Lechosław Putowski, Sylwia Chocholska |
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Rok vydání: | 2014 |
Předmět: |
Adult
Male Cancer Research Chronic lymphocytic leukemia Mrna expression Time to treatment chemical and pharmacologic phenomena CD38 CD19 Time-to-Treatment Flow cytometry Andrology parasitic diseases medicine Humans Aged B-Lymphocytes biology medicine.diagnostic_test Gene Expression Regulation Leukemic Cell Membrane hemic and immune systems Hematology Middle Aged Prognosis medicine.disease Leukemia Lymphocytic Chronic B-Cell Survival Analysis Up-Regulation Staining carbohydrates (lipids) Oncology Case-Control Studies CD1D Immunology biology.protein Female lipids (amino acids peptides and proteins) Antigens CD1d |
Zdroj: | Leukemia Research. 38:435-442 |
ISSN: | 0145-2126 |
Popis: | Through the analysis of CD1d expression by flow cytometry and qRT-PCR we showed lower CD1d molecule and CD1d mRNA expression in B cells of CLL patients than of healthy controls. The frequency of CD1d + /CD19 + cells, CD1d staining intensity and CD1d transcript levels increased with the disease stage. CD1d expression was positively associated with ZAP-70 and CD38 expressions as well as with unfavourable cytogenetic changes. We established the relationship between high CD1d expression and shorter time to treatment and overall survival. We observed that CD1d expression in individual patients significantly changed over time. The percentage of CD1d + /CD19 + cells inversely correlated with the percentage of iNKT cells. |
Databáze: | OpenAIRE |
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