Improvement of memory recall by quercetin in rodent contextual fear conditioning and human early-stage Alzheimer’s disease patients
| Autor: | Shimo Li, Emika Nishida, Masashi Ueda, Hiroshi Akanabe, Saiful Islam, Kiyomi Nakagawa, Daisuke Yanagida, Takato Muro, Miki Hayakawa, Ryo Nakabayashi, Takashi Inuzuka, Yoshinori Itoh, Kazunori Ohta, Kazuki Saito, Tetsuya Mori, Tokio Chikaishi, Masanori T. Itoh, Kaori Ohzawa, Tana, Chihiro Suzuki, Yasushi Yamada, Masuko Kobori, Miao-xing Wang, Toshiyuki Nakagawa, Yuichi Hayashi |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Disease Audiology Neuropsychological Tests Antioxidants Developmental psychology 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Alzheimer Disease Conditioning Psychological medicine Explicit memory Dementia Animals Humans heterocyclic compounds Benzothiazoles Aged Aged 80 and over Memory Disorders Aniline Compounds Recall General Neuroscience fungi food and beverages Cognition Fear medicine.disease Iofetamine Mental Status and Dementia Tests Magnetic Resonance Imaging Mice Inbred C57BL Thiazoles 030104 developmental biology chemistry Positron-Emission Tomography Mental Recall Conditioning Female Quercetin Alzheimer's disease Psychology 030217 neurology & neurosurgery |
| Zdroj: | SC30201706210018 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/WNR.0000000000000594 |
| Popis: | Patients with Alzheimer's disease (AD) experience a wide array of cognitive deficits, which typically include the impairment of explicit memory. In previous studies, the authors reported that a flavonoid, quercetin, reduces the expression of ATF4 and delays memory deterioration in an early-stage AD mouse model. In the present study, the effects of long-term quercetin intake on memory recall were assessed using contextual fear conditioning in aged wild-type mice. In addition, the present study examined whether memory recall was affected by the intake of quercetin-rich onion (a new cultivar of hybrid onion 'Quergold') powder in early-stage AD patients. In-vivo analysis indicated that memory recall was enhanced in aged mice fed a quercetin-containing diet. Memory recall in early-stage AD patients, determined using the Revised Hasegawa Dementia Scale, was significantly improved by the intake of quercetin-rich onion (Quergold) powder for 4 weeks compared with the intake of control onion ('Mashiro' white onion) powder. These results indicate that quercetin might influence memory recall. |
| Databáze: | OpenAIRE |
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