Urinary soluble (pro)renin receptor excretion is associated with urine pH in humans

Autor: Chikahito Suda, Satoshi Morimoto, Nobukazu Sasaki, Satoru Shimizu, Atsuhiro Ichihara
Rok vydání: 2021
Předmět:
0301 basic medicine
Physiology
Organic chemistry
Blood Pressure
Urine
030204 cardiovascular system & hematology
Kidney
Biochemistry
Vascular Medicine
Body Mass Index
Renin-Angiotensin System
0302 clinical medicine
Renin
Medicine and Health Sciences
Vitamin C
Receptor
health care economics and organizations
Multidisciplinary
Chemistry
Vitamins
Hydrogen-Ion Concentration
Middle Aged
Body Fluids
Physical sciences
Blood
medicine.anatomical_structure
Physiological Parameters
Creatinine
Hypertension
Medicine
Anatomy
geographic locations
Research Article
Glomerular Filtration Rate
Adult
Vacuolar Proton-Translocating ATPases
medicine.medical_specialty
Science
Urinary system
education
Excretion
Renal function
Receptors
Cell Surface
Chemical compounds
03 medical and health sciences
health services administration
Internal medicine
Organic compounds
Renin–angiotensin system
medicine
Humans
Kidney Tubules
Collecting
Renal Physiology
Body Weight
Biology and Life Sciences
Biological Transport
030104 developmental biology
Endocrinology
Physiological Processes
Biomarkers
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254688 (2021)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0254688
Popis: The (pro)renin receptor [(P)RR] binds to renin and its precursor prorenin to activate the tissue renin-angiotensin system. It is cleaved to generate soluble (P)RR and M8–9, a residual hydrophobic truncated protein. The (pro)renin receptor also functions as an intracellular accessory protein of vacuolar-type H+-ATPase, which plays an essential role in controlling the intracellular vesicular acid environment. Thus, in the kidney, (P)RR may play a role in transporting H+ to urine in the collecting duct. Although blood soluble (P)RR has been recognized as a biomarker reflecting the status of the tissue renin-angiotensin system and/or tissue (P)RR, the significance of urinary soluble (P)RR excretion has not been determined. Therefore, this study aimed to investigate the characteristics of urinary soluble (P)RR excretion. Urinary soluble (P)RR excretion was measured, and its association with background factors was investigated in 441 patients. Relationships between changes in urine pH due to vitamin C treatment, which reduce urine pH, and urinary soluble (P)RR excretion were investigated in 10 healthy volunteers. Urinary soluble (P)RR excretion was 1.46 (0.44–2.92) ng/gCre. Urine pH showed a significantly positive association with urinary soluble (P)RR excretion, independent of other factors. Changes in urine pH and urinary soluble (P)RR excretion due to vitamin C treatment were significantly and positively correlated (ρ = 0.8182, p = 0.0038). These data showed an association between urinary soluble (P)RR excretion and urine pH in humans, suggesting that (P)RR in the kidney might play a role in urine pH regulation.
Databáze: OpenAIRE
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