A highly selective quinolizinium-based fluorescent probe for cysteine detection

Autor:	Caifeng Xu, Wing-Cheung Chan, Jie-Ren Deng, Wa-Yi O, Man-Kin Wong, Ben C.B. Ko
Rok vydání:	2021
Předmět:	Detection limit chemistry.chemical_classification Chromatography Homocysteine General Chemical Engineering General Chemistry Glutathione Fluorescence Amino acid chemistry.chemical_compound chemistry Cytotoxicity Quantitative analysis (chemistry) Cysteine
Zdroj:	RSC Advances. 11:33294-33299
ISSN:	2046-2069
DOI:	10.1039/d1ra06104f
Popis:	A novel fluorescent quinolizinium-based turn-off probe has been developed for selective detection of cysteine. The probe showed high selectivity and sensitivity towards cysteine over other amino acids including the similarly structured homocysteine and glutathione with a detection limit of 0.18 μM (S/N = 3). It was successfully applied to cysteine detection in living cells with low cytotoxicity and quantitative analysis of spiked mouse serum samples with moderate to good recovery (96-109%).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337fa5e6e8e66b5922bff2a8a75e2403 https://doi.org/10.1039/d1ra06104f Zobrazit plný text záznamu