Cathepsin K inhibitor causes changes in crystallinity and crystal structure of newly-formed mandibular bone in rats
| Autor: | Seiji Iida, Yasuhiro Kobayashi, Eiki Yamachika, Tatsuo Fujii, Kazuki Nakatsuji, Tadashi Ninomiya, Makoto Nakanishi, Y. Yoshioka |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Cathepsin K Osteoporosis 030209 endocrinology & metabolism Mandible 03 medical and health sciences Crystallinity 0302 clinical medicine Bone Density Internal medicine medicine Animals Rats Wistar biology business.industry Biphenyl Compounds medicine.disease Rats Raman microspectroscopy Resorption 030104 developmental biology Mineral density Endocrinology Otorhinolaryngology Proteoglycan biology.protein Female Surgery Oral Surgery Tomography X-Ray Computed Osteonecrosis of the jaw business |
| Zdroj: | British Journal of Oral and Maxillofacial Surgery. 56:732-738 |
| ISSN: | 0266-4356 |
| Popis: | Cathepsin K inhibitors are new drugs with the potential for the treatment of osteoporosis because they sustain bony remodelling better than bone resorption inhibitors such as bisphosphonates. The treatment of osteoporosis with inhibitors of bony resorption is associated with osteonecrosis of the jaw, as the deterioration in bony quality that they induce is thought to be one of its causes. The quality of bone is delineated by structural and material characteristics (which include the degree and quality of mineralisation, and depends on the content of proteoglycan and the structural integrity of the bony collagen).1,2 Animal and clinical studies have shown that cathepsin K inhibitors improve the mineral density and structural characteristics of bone, but their effect on the rest remains unknown. We therefore hypothesised that these inhibitors will affect the material characteristics of newly-formed mandibular bone. To verify our hypothesis, we used Raman microspectroscopy to examine such bone in rats that were given a cathepsin K inhibitor, and found unusual crystallinity and an increased substitution of carbonate (CO32-) in its crystal structure. |
| Databáze: | OpenAIRE |
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