Sensory nerves in the airways as a target for drug development
| Autor: | M. P. Rechtman |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Agonist
Male medicine.medical_specialty Physiology medicine.drug_class Bronchoconstriction Guinea Pigs Indomethacin Receptors Opioid mu Substance P Stimulation Bronchi Pentolinium chemistry.chemical_compound Thromboxane A2 Physiology (medical) Internal medicine medicine Animals Neurons Afferent Pharmacology Arachidonic Acid Temperature Azepines Electric Stimulation Endocrinology medicine.anatomical_structure chemistry Drug Design Receptors Opioid Capsaicin Tachykinin receptor Idazoxan Adrenergic alpha-Agonists Oligopeptides medicine.drug Sensory nerve |
| Zdroj: | Clinical and experimental pharmacologyphysiology. 19(1) |
| ISSN: | 0305-1870 |
| Popis: | SUMMARY 1. Electrical stimulation (2.5–10 Hz, 80 V, 1 ms for 15 s) within the spinal canal of the pithed guinea-pig pretreated with atropine, D-tubocurarine and pentolinium caused a bronchoconstrictor response, indicated by a rise of insufflation pressure. 2. The magnitude of these non-cholinergic neuronal bronchoconstrictor responses were frequency-dependent, capsaicin-sensitive and temperature-dependent. 3. Responses could be inhibited by the α2-adrenoceptor agonist B-HT920 (3 mg/kg, i.v.) and the μ-opioid agonist H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA; 1 mg/kg, i.v.) and the attenuation observed could be overcome by use of the respective antagonists idazoxan (3 mg/kg, i.v.) and naloxone (3 mg/kg, i.v.). 4. Substance P-induced bronchoconstriction (0.3 μg/kg, i.v.), but not that due to electrical stimulation, was attenuated by indomethacin (3 mg/kg, i.v.), indicating an indirect action of substance P via a product of arachidonic acid metabolism. 5. The prostanoid product of the substance P response was probably thromboxane A2. 6. Hence, novel drug development could be directed towards tachykinin receptors or to the synthesis, release and degradation of neuropeptides. |
| Databáze: | OpenAIRE |
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