The interface of hypothalamic-pituitary-adrenocortical axis and circulating brain natriuretic peptide in prediction of cardiopulmonary performance during physical stress
| Autor: | Bosiljka Plećaš-Solarović, Dejana Popovic, Svetozar Damjanovic, Vesna Pešić, Marko Banovic, Vidan Markovic, Ivana Petrović, Stanimir Stojiljković, Miodrag Ostojic, Vladan Vukcevic, Arsen D. Ristić, Bosiljka Vujisic-Tesic, Bojana Popovic, Milan Petrovic |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Hypothalamo-Hypophyseal System endocrine system Hydrocortisone Physiology Pituitary-Adrenal System Adrenocorticotropic hormone Stress axis 030204 cardiovascular system & hematology Biochemistry Cortisol 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Endocrinology Oxygen Consumption Adrenocorticotropic Hormone Heart Rate Stress Physiological Internal medicine Heart rate Natriuretic Peptide Brain medicine Humans Cardiopulmonary test Treadmill Body surface area Radioimmunoassay Carbon Dioxide Brain natriuretic peptide Peptide Fragments Physical stress Athletes Hypothalamic-pituitary-adrenocortical axis Exercise Test Physical Endurance Psychology human activities 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists |
| Zdroj: | Peptides |
| Popis: | Brain natriuretic peptide (NT-pro-BNP) was implicated in the regulation of hypothalamic-pituitary-adrenocortical (HPA) responses to psychological stressors. However, HPA axis activation in different physical stress models and its interface with NT-pro-BNP in the prediction of cardiopulmonary performance is unclear. Cardiopulmonary test on a treadmill was used to assess cardiopulmonary parameters in 16 elite male wrestlers (W), 21 water polo player (WP) and 20 sedentary age-matched subjects (C). Plasma levels of NT-pro-BNP, cortisol and adrenocorticotropic hormone (ACTH) were measured using immunoassay sandwich technique, radioimmunoassay and radioimmunometric techniques, respectively, 10min before test (1), at beginning (2), at maximal effort (3), at 3rdmin of recovery (4). In all groups, NT-pro-BNP decreased between 1 and 2; increased from 2 to 3; and remained unchanged until 4. ACTH increased from 1 to 4, whereas cortisol increased from 1 to 3 and stayed elevated at 4. In all groups together, ΔNT-pro-BNP2/1 predicted peak oxygen consumption (B=37.40, r=0.38, p=0.007); cortisol at 3 predicted heart rate increase between 2 and 3 (r=-0.38,B=-0.06, p=0.005); cortisol at 2 predicted peak carbon-dioxide output (B=2.27, r=0.35, p |
| Databáze: | OpenAIRE |
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