Plasma Transfusion Demystified: A Review of the Key Factors Influencing the Response to Plasma Transfusion
| Autor: | Williams La rd, Elizabeth M. Staley, Alexander Z. Feldman, Kennell T, Huy P. Pham, Allen W. Bryan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Blood transfusion business.industry Plasma transfusions medicine.medical_treatment Biochemistry (medical) Clinical Biochemistry Blood Component Transfusion Review 030204 cardiovascular system & hematology Blood coagulation factors 03 medical and health sciences Patient safety 0302 clinical medicine Key factors Practice Guidelines as Topic Prothrombin Time Medicine Humans International Normalized Ratio business Intensive care medicine 030215 immunology |
| Zdroj: | Laboratory medicine. 48(2) |
| ISSN: | 1943-7730 |
| Popis: | Many studies have suggested that inappropriate plasma usage is common. An important factor contributing to futile plasma administration in most patients is the nonlinear relationship between coagulation-factor levels and the volume of plasma transfused. In this review, a validated mathematical model and data from the literature will be used to illuminate 3 key properties of plasma transfusion. Those properties are as follows: the effect of plasma transfusion on international normalized ratio (INR) is transient; for the same volume of transfused plasma, a greater reduction in INR is observed at higher initial INRs; and the effect of plasma transfusion on INR correction (ie, the difference between initial and final INRs) diminishes as more plasma is transfused. Frequent misunderstanding of these properties may contribute to inappropriate plasma usage. Therefore, this review will assist physicians in navigating these common pitfalls. Stronger understanding of these principles may result in a reduction of inappropriate plasma transfusions, thus potentially enhancing patient safety and reducing healthcare costs. |
| Databáze: | OpenAIRE |
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