Serum amyloid A in Alzheimer's disease brain is predominantly localized to myelin sheaths and axonal membrane
| Autor: | Robin J. Johnson, Barbara M. Schreiber, J S Liang, R E Fine, Ann C. McKee, Tzu-Feng Chung, Jean D. Sipe |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Pathology medicine.medical_specialty Presynaptic Terminals Biology White matter Myelin Alzheimer Disease Internal Medicine medicine Humans Serum amyloid A Protein Precursors Serum Amyloid A Protein Myelin Sheath Aged Aged 80 and over Dementia with Lewy bodies Multiple sclerosis Cholesterol binding Cell Membrane Brain Middle Aged medicine.disease medicine.anatomical_structure Apolipoproteins Alzheimer's disease |
| Zdroj: | Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 7(2) |
| ISSN: | 1350-6129 |
| Popis: | Immunohistochemical localization of the injury specific apolipoprotein, acute phase serum amyloid A (A-apoSAA), was compared in brains of patients with neuropathologically confirmed Alzheimer's disease (AD), multiple sclerosis (MS), Parkinson's disease (PD); Pick's disease (Pick's), dementia with Lewy bodies (DLB), coronary artery disease (CAD), and schizophrenia. Affected regions of both AD and MS brains showed intense staining for A-apoSAA in comparison to an unaffected region and non-AD/MS brains. The major site of A-apoSAA staining in both diseases was the myelin sheaths of axons in layers V and VI of affected cortex. A-apoSAA contains a cholesterol binding site near its amino terminus and is likely to have a high affinity for cholesterol-rich myelin. These findings, along with our recent evidence that A-apoSAA can inhibit lipid synthesis in vascular smooth muscle cells suggest that A-apoSAA plays a role in the neuronal loss and white matter damage occurring in AD and MS. |
| Databáze: | OpenAIRE |
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