Transition‐Metal‐Free Valorization of Biomass‐derived Levulinic Acid Derivatives: Synthesis of Curcumene and Xanthorrhizol

Autor:	Yao Fu, Wen-Yan Xu, Kai-Feng Zhuo, Tian-Jun Gong
Rok vydání:	2020
Předmět:	Tosylhydrazone Acylation chemistry.chemical_compound General Energy Transition metal Chemistry General Chemical Engineering Levulinic acid Environmental Chemistry Organic chemistry Biomass Molecule General Materials Science
Zdroj:	ChemSusChem. 14:884-891
ISSN:	1864-564X 1864-5631
DOI:	10.1002/cssc.202002167
Popis:	Levulinic acid (LA) is acknowledged one of the most promising biomass-derived platform molecules, and can be transformed into various value-added chemicals. Here, we report a new reaction process for the valorization of levulinic acid derivatives under transition-metal free condition. The protocol combined with the conversion of the levulinate to tosylhydrazone and base promoted arylation, acylation, and etherification cross-coupling. Moreover, our method was applied to synthesize three biologically active molecules, rac-curcumene, rac-xanthorrhizol and rac-4,7-dimethyl-l-tetralone. This reaction discloses a new avenue for the high-value utilization of platform molecules.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3377a7e3fce3f396d43e9003eb13b285 https://doi.org/10.1002/cssc.202002167 Zobrazit plný text záznamu Plný text