Piperidine-based renin inhibitors: Upper chain optimization

Autor:	Lars Prade, Panja Strickner, Corinna Grisostomi, Beat Steiner, Walter Fischli, Alexander Treiber, Daniel Bur, Olivier Bezencon, Ľuboš Remeň, Patrick Hess, Sylvia Richard-Bildstein, Olivier Corminboeuf
Rok vydání:	2010
Předmět:	Models Molecular Stereochemistry medicine.drug_class Clinical Biochemistry Angiotensinogen Pharmaceutical Science Biochemistry Chemical synthesis Renin inhibitor Animals Genetically Modified Structure-Activity Relationship chemistry.chemical_compound Piperidines Renin Drug Discovery Renin–angiotensin system medicine Animals Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Humans Enzyme Inhibitors Molecular Biology chemistry.chemical_classification biology Organic Chemistry Stereoisomerism Rats Enzyme chemistry Enzyme inhibitor Benzene derivatives biology.protein Molecular Medicine Indicators and Reagents Piperidine Aspartic Endopeptidases
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 20:6291-6296
ISSN:	0960-894X
Popis:	The optimization of the 4-position of recently described new 3,4-disubstituted piperidine-based renin inhibitors is reported herein. The synthesis and characterization of compounds leading to the discovery of 11 (ACT-178882, MK-1597), a renin inhibitor with a suitable profile for development is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3375e80e5e2a680af0000f459f284a18 https://doi.org/10.1016/j.bmcl.2010.08.087 Zobrazit plný text záznamu Full Text from ScienceDirect