IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function

Autor: Moshe Elkabets, Christian A. J. Vosshenrich, Charles A. Dinarello, Suzanne Ostrand-Rosenberg, Vera S. G. Ribeiro, James P. Di Santo, Ron N. Apte
Přispěvatelé: Immunité Innée, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Shraga Segal Department of Microbiology and Immunology, The Cancer Research Center, Ben-Gurion University of the Negev (BGU), PhD Programme in Experimental Biology and Biomedicine, Center for Neurosciences and Cell Biology, University of Coimbra, Department of Medicine [Denver], University of Colorado Anschutz [Aurora], Department of Biological Sciences [Baltimore], University of Maryland [Baltimore County] (UMBC), University of Maryland System-University of Maryland System, Israel Ministry of Health Chief Scientist's Office German-Israeli DIP collaborative program (Deutsche-Israelische Projektkooperation) Israel Academy of Sciences and Humanities Ministry of Science and Technology (MOST), Vosshenrich, Christian, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2010
Předmět:
Cytotoxicity
Immunologic
Cellular differentiation
Immunology
Cell
Interleukin-1beta
Biology
[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity
Article
Immune tolerance
03 medical and health sciences
Mice
0302 clinical medicine
Immune system
Cell Line
Tumor
medicine
Immune Tolerance
Immunology and Allergy
Animals
Antigens
Ly
Myeloid Cells
[SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity
Immunologic Surveillance
030304 developmental biology
Mice
Knockout
0303 health sciences
Tumor microenvironment
Mice
Inbred BALB C
Cell growth
Carcinoma
Cell Differentiation
Neoplasms
Experimental
Antigens
Differentiation
3. Good health
Cell biology
Killer Cells
Natural
medicine.anatomical_structure
Tumor progression
030220 oncology & carcinogenesis
Myeloid-derived Suppressor Cell
Tumor Escape
Inflammation Mediators
Zdroj: European Journal of Immunology
European Journal of Immunology, 2010, ⟨10.1002/eji.201041037⟩
European Journal of Immunology, Wiley-VCH Verlag, 2010, ⟨10.1002/eji.201041037⟩
ISSN: 1521-4141
0014-2980
DOI: 10.1002/eji.201041037⟩
Popis: International audience; Chronic inflammation is associated with promotion of malignancy and tumor progression. Many tumors enhance the accumulation of myeloid-derived suppressor cells (MDSC), which contribute to tumor progression and growth by suppressing anti-tumor immune responses. Tumor-derived IL-1β secreted into the tumor microenvironment has been shown to induce the accumulation of MDSC possessing an enhanced capacity to suppress T cells. In this study, we found that the enhanced suppressive potential of IL-1β-induced MDSC was due to the activity of a novel subset of MDSC lacking Ly6C expression. This subset was present at low frequency in tumor-bearing mice in the absence of IL-1β-induced inflammation; however, under inflammatory conditions, Ly6C(neg) MDSC were predominant. Ly6C(neg) MDSC impaired NK cell development and functions in vitro and in vivo. These results identify a novel IL-1β-induced subset of MDSC with unique functional properties. Ly6C(neg) MDSC mediating NK cell suppression may thus represent useful targets for therapeutic interventions.
Databáze: OpenAIRE
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