A novel SWCNT platform bearing DOTA and β-cyclodextrin units. 'One shot' multidecoration under microwave irradiation
| Autor: | Giancarlo Cravotto, D. Lembo, Alessandro Barge, E. Calcio Gaudino, Marco Lucio Lolli, Enzo Terreno, Silvia Tagliapietra, Katia Martina |
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| Rok vydání: | 2014 |
| Předmět: |
Thermogravimetric analysis
Cell Survival Chemistry Organic Carbon nanotube Decarboxylation Biochemistry law.invention Heterocyclic Compounds 1-Ring chemistry.chemical_compound law Cell Line Tumor Polymer chemistry Humans DOTA Organic chemistry Moiety Physical and Theoretical Chemistry Microwaves chemistry.chemical_classification Cycloaddition Reaction Cyclodextrin Nanotubes Carbon beta-Cyclodextrins Organic Chemistry Temperature Grafting Phenolphthalein chemistry Surface modification Spectrophotometry Ultraviolet |
| Zdroj: | Org. Biomol. Chem.. 12:4708-4715 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/c4ob00611a |
| Popis: | The functionalization of single-walled carbon nanotubes (SWCNTs) via microwave-assisted grafting reactions enables efficient multidecoration in a single step. A novel water-soluble SWCNT platform was prepared via the simple 1,3-dipolar cycloaddition of azomethine ylides under dielectric heating. Thanks to a single grafting reaction the CNT surface binds in a 1 : 1 ratio an amino acidic β-cyclodextrin (β-CD) derivative and the DOTAMA moiety (1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid monoamide). This novel "one shot" synthesis, compared with multistep functionalizations, preserves the SWCNT's structural integrity (TEM images). Besides thermogravimetric analyses, the determination of the amount of β-CD and DOTA moieties grafting onto the SWCNT's surface was performed on the basis of phenolphthalein and gadolinium complexation, respectively. |
| Databáze: | OpenAIRE |
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