A comparison of epidermal growth factor receptor levels and other prognostic parameters in non-small cell lung cancer
| Autor: | Noriaki Tezuka, Shozo Fujino, T. Enokibori, Hirofumi Kato, Atsumi Mori, Yoshikuni Asada, Shuhei Inoue |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Biology Radioligand Assay Sex Factors Epidermal growth factor Internal medicine Carcinoma Non-Small-Cell Lung medicine Carcinoma Biomarkers Tumor Humans Epidermal growth factor receptor Receptor Lung cancer Aged Neoplasm Staging Aged 80 and over Ploidies Growth factor Respiratory disease Age Factors Middle Aged medicine.disease Prognosis ErbB Receptors Cytokine Endocrinology Oncology Lymphatic Metastasis biology.protein Female |
| Zdroj: | European journal of cancer (Oxford, England : 1990). (12) |
| ISSN: | 0959-8049 |
| Popis: | Epidermal growth factor receptor (EGFR) was measured using a competitive radioligand binding assay in membrane preparations from 74 primary human non-small cell lung cancer (NSCLC) tissues and 20 pathologically normal peripheral lung tissues. The mean EGFR level in tumours was 30.38 fmol/mg (+/-41.95 S.D.) of membrane protein (mg.p), significantly higher (P = 0.00016) than in normal tissues (mean, 10.26 +/- 10.02 fmol/mg.p). The mean EGFR concentration was also significantly higher in pathological stage IV tissue than in stages I (P = 0.049) and II (P = 0.040), and the mean EGFR concentration was significantly higher in cases with mediastinal involvement than in cases without it (P = 0.029). The mean EGFR level was higher in DNA aneuploid and multiploid cases than in DNA diploid cases, but there was no significant difference. No significant relationships were found to exist between receptor concentrations and pathological tumour size or histological type, or patient gender or age. From the above findings, a possible prognostic role for EGFR in primary NSCLC should be investigated. |
| Databáze: | OpenAIRE |
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